Cargando…

Evaluation of non-clinical toxicity studies of COVID-19 vaccines

In this study we evaluated the outcomes of non-clinical toxicity studies of various SARS-CoV-2 vaccines produced with different manufacturing technologies, with focus on Repeated Dose Toxicity (RDT) and Developmental and Reproductive Toxicity (DART) studies. We found that RDT and DART studies at dos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schilder, N.K.M., Tiesjema, B., Theunissen, P.T., Rengerink, K. Oude, van der Laan, J.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289821/ https://www.ncbi.nlm.nih.gov/pubmed/37356612 http://dx.doi.org/10.1016/j.yrtph.2023.105438

Ejemplares similares

A narrative review of estimands in drug development and regulatory evaluation: old wine in new barrels?
por: Mitroiu, M., et al.
Publicado: (2020)

Estimation of treatment effects in short‐term depression studies. An evaluation based on the ICH E9(R1) estimands framework
por: Mitroiu, Marian, et al.
Publicado: (2022)

Fair inclusion of pregnant women in clinical trials: an integrated scientific and ethical approach
por: van der Graaf, Rieke, et al.
Publicado: (2018)

Inhibitor development in previously untreated patients with severe haemophilia: A comparison of included patients and outcomes between a clinical study and a registry‐based study
por: Jonker, Carla J., et al.
Publicado: (2020)

Pregnant womens’ concerns when invited to a randomized trial: a qualitative case control study
por: Oude Rengerink, Katrien, et al.
Publicado: (2015)

Delivery-related risk factors for covert postpartum urinary retention after vaginal delivery
por: Mulder, Femke E. M., et al.
Publicado: (2015)

Radiotherapy for COVID-19: Primum non nocere()
por: Boon, Ian S., et al.
Publicado: (2020)

Community Use of Repurposed Drugs Before and During COVID-19 Pandemic in the Netherlands: An Interrupted Time-Series Analysis
por: Zhou, Guiling, et al.
Publicado: (2023)

Preliminary clinical assessment and non- toxicity evaluation of an ayurvedic formulation BGR-34 in NIDDM
por: Gupta, B.P., et al.
Publicado: (2018)

Perspectives of Healthcare Professionals Towards Combination Use of Oral Paracetamol and Topical Non-Steroidal Inflammatory Drugs in Managing Mild-to-Moderate Pain for Osteoarthritis in a Clinical Setting: An Exploratory Study
por: Sethi, Vidhu, et al.
Publicado: (2022)

Repurposing drugs as COVID-19 therapies: A toxicity evaluation
por: Ngan, Deborah K., et al.
Publicado: (2022)

Design of an Expert System for Mitigating Trace Element Toxicity in Cancer Risk Management
por: Krishna Kumar, P.T., et al.
Publicado: (2013)

COVID-19 vaccine: Various toxicities: case report
Publicado: (2022)

Burden of respiratory syncytial virus bronchiolitis on the Dutch pediatric intensive care units
por: Linssen, Rosalie S., et al.
Publicado: (2021)

Bioengineering Liver Transplantation
por: Verstegen, Monique M.A., et al.
Publicado: (2019)

Influenza Vaccination and Mortality: Differentiating Vaccine Effects From Bias
por: Fireman, Bruce, et al.
Publicado: (2009)

COVID-19-vaccines: Various toxicities: 314 case reports
Publicado: (2021)

Call for Papers on potential toxic effects of COVID-19 vaccines
por: Domingo, José L.
Publicado: (2022)

Evaluation of RNA isolation methods for microRNA quantification in a range of clinical biofluids
por: Roest, Henk P., et al.
Publicado: (2021)

Child and adolescent COVID-19 vaccination status and reasons for non-vaccination by parental vaccination status()
por: Nguyen, K.H., et al.
Publicado: (2022)

Pharmacological pain relief and fear of childbirth in low risk women; secondary analysis of the RAVEL study
por: Logtenberg, Sabine L. M., et al.
Publicado: (2018)

Non‐clinical considerations for supporting accelerated inclusion of pregnant women in pre‐licensure clinical trials with anti‐HIV agents
por: Greupink, Rick, et al.
Publicado: (2022)

Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity
por: van der Laan, Luc J.W., et al.
Publicado: (2021)

Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta)
por: Kumar, B. Dinesh, et al.
Publicado: (2013)

Patients’ preferences for telemedicine versus in-clinic consultation in primary care during the COVID-19 pandemic
por: Mozes, I., et al.
Publicado: (2022)

COVID-19: Clinical Challenges in Dutch Geriatric Psychiatry
por: Naarding, P., et al.
Publicado: (2020)

Shedding the Light on Post-Vaccine Myocarditis and Pericarditis in COVID-19 and Non-COVID-19 Vaccine Recipients
por: Hajjo, Rima, et al.
Publicado: (2021)

Establishment and evaluation of scalable COVID-19 vaccine clinics at a large university
por: Garofoli, Gretchen K., et al.
Publicado: (2022)

COVID-19-vaccine-pfizer-biontech: Various toxicities: case report
Publicado: (2022)

Clozapine/COVID-19-vaccine: Various toxicities: 2 case reports
Publicado: (2022)

Immune correlates analysis of the PREVENT-19 COVID-19 vaccine efficacy clinical trial
por: Fong, Youyi, et al.
Publicado: (2023)

Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease
por: de Krijger, Manon, et al.
Publicado: (2020)

Teaching trainers to incorporate evidence-based medicine (EBM) teaching in clinical practice: the EU-EBM project
por: Thangaratinam, Shakila, et al.
Publicado: (2009)

AZD-1222/COVID-19-vaccine/COVID-19-Vaccine-Pfizer-BioNTech: Various toxicities: 5 case reports
Publicado: (2021)

Letter to the Editor: High Mobility Group Box Protein 1 Release Is an Identified Driver of Inflammation in the Pathogenesis of Biliary Atresia
por: Shi, Shaojun, et al.
Publicado: (2021)

Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations
por: Yang, Ming-Yan, et al.
Publicado: (2022)

IMproving PArticipation of patients in Clinical Trials - rationale and design of IMPACT
por: Oude Rengerink, Katrien, et al.
Publicado: (2010)

COVID-19 vaccination-related exacerbation of seizures in persons with epilepsy()
por: Pang, E.W., et al.
Publicado: (2023)

A safety study evaluating non-COVID-19 mortality risk following COVID-19 vaccination
por: Xu, Stanley, et al.
Publicado: (2023)

Toxic Epidermal Necrolysis Post COVID-19 Vaccination - First Reported Case
por: Bakir, Mohamad, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v2tslvuf4b4npdei53p9ppm7hm