Cell targeting and immunostimulatory properties of a novel Fcγ-receptor-independent agonistic anti-CD40 antibody in rhesus macaques

Targeting CD40 by agonistic antibodies used as vaccine adjuvants or for cancer immunotherapy is a strategy to stimulate immune responses. The majority of studied agonistic anti-human CD40 antibodies require crosslinking of their Fc region to inhibitory FcγRIIb to induce immune stimulation although t...

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Detalles Bibliográficos
Autores principales: Yan, Xianglei, Ols, Sebastian, Arcoverde Cerveira, Rodrigo, Lenart, Klara, Hellgren, Fredrika, Ye, Kewei, Cagigi, Alberto, Buggert, Marcus, Nimmerjahn, Falk, Falkesgaard Højen, Jesper, Parera, Daniel, Pessara, Ulrich, Fischer, Stephan, Loré, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289945/
https://www.ncbi.nlm.nih.gov/pubmed/37353664
http://dx.doi.org/10.1007/s00018-023-04828-2

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