Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage

Mesenchymal stromal cells (MSCs) are a key component of the bone marrow (BM) niche, providing essential support required for the maintenance of hematopoietic stem cells. To advance our understanding of physiological functions of p53 and Mdm2 in BM-MSCs, we developed traceable conditional mouse model...

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Detalles Bibliográficos
Autores principales: Pourebrahim, Rasoul, Heinz Montoya, Rafael, Alaniz, Zoe, Ostermann, Lauren, Lin, Patrick P., Liu, Bin, Ayoub, Edward, Burks, Jared K., Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290070/
https://www.ncbi.nlm.nih.gov/pubmed/37353528
http://dx.doi.org/10.1038/s41419-023-05844-7

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