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NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization

Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor function remains incompletely understood. Here we show that NUP98 and RAE1 are highly expressed in epidermal progenitors, forming a separate complex in...

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Detalles Bibliográficos
Autores principales: Neely, Amy E., Blumensaadt, Laura A., Ho, Patric J., Lloyd, Sarah M., Kweon, Junghun, Ren, Ziyou, Bao, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290086/
https://www.ncbi.nlm.nih.gov/pubmed/37353594
http://dx.doi.org/10.1038/s42003-023-05043-2