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Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression
Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studies have shown shorter TL to be associated with poorer respon...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290110/ https://www.ncbi.nlm.nih.gov/pubmed/37353495 http://dx.doi.org/10.1038/s41598-023-35912-z |
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author | Rampersaud, Ryan Wu, Gwyneth W. Y. Reus, Victor I. Lin, Jue Blackburn, Elizabeth H. Epel, Elissa S. Hough, Christina M. Mellon, Synthia H. Wolkowitz, Owen M. |
author_facet | Rampersaud, Ryan Wu, Gwyneth W. Y. Reus, Victor I. Lin, Jue Blackburn, Elizabeth H. Epel, Elissa S. Hough, Christina M. Mellon, Synthia H. Wolkowitz, Owen M. |
author_sort | Rampersaud, Ryan |
collection | PubMed |
description | Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studies have shown shorter TL to be associated with poorer response to certain psychotropic medications, and our previous work suggested shorter TL and higher telomerase activity (TA) predicts poorer response to Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Using a new group of unmedicated medically healthy individuals with MDD (n = 48), we sought to replicate our prior findings demonstrating that peripheral blood mononuclear cell (PBMC) TL and TA predict response to SSRI treatment and to identify associations between TL and TA with biological stress mediators and cardiometabolic risk indices. Our results demonstrate that longer pre-treatment TL was associated with better response to SSRI treatment (β = .407 p = .007). Additionally, we observed that TL had a negative relationship with allostatic load (β = − .320 p = .017) and a cardiometabolic risk score (β = − .300 p = .025). Our results suggest that PBMC TL reflects, in part, the cumulative effects of physiological stress and cardiovascular risk in MDD and may be a biomarker for predicting SSRI response. |
format | Online Article Text |
id | pubmed-10290110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102901102023-06-25 Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression Rampersaud, Ryan Wu, Gwyneth W. Y. Reus, Victor I. Lin, Jue Blackburn, Elizabeth H. Epel, Elissa S. Hough, Christina M. Mellon, Synthia H. Wolkowitz, Owen M. Sci Rep Article Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studies have shown shorter TL to be associated with poorer response to certain psychotropic medications, and our previous work suggested shorter TL and higher telomerase activity (TA) predicts poorer response to Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Using a new group of unmedicated medically healthy individuals with MDD (n = 48), we sought to replicate our prior findings demonstrating that peripheral blood mononuclear cell (PBMC) TL and TA predict response to SSRI treatment and to identify associations between TL and TA with biological stress mediators and cardiometabolic risk indices. Our results demonstrate that longer pre-treatment TL was associated with better response to SSRI treatment (β = .407 p = .007). Additionally, we observed that TL had a negative relationship with allostatic load (β = − .320 p = .017) and a cardiometabolic risk score (β = − .300 p = .025). Our results suggest that PBMC TL reflects, in part, the cumulative effects of physiological stress and cardiovascular risk in MDD and may be a biomarker for predicting SSRI response. Nature Publishing Group UK 2023-06-23 /pmc/articles/PMC10290110/ /pubmed/37353495 http://dx.doi.org/10.1038/s41598-023-35912-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rampersaud, Ryan Wu, Gwyneth W. Y. Reus, Victor I. Lin, Jue Blackburn, Elizabeth H. Epel, Elissa S. Hough, Christina M. Mellon, Synthia H. Wolkowitz, Owen M. Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title | Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title_full | Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title_fullStr | Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title_full_unstemmed | Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title_short | Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
title_sort | shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290110/ https://www.ncbi.nlm.nih.gov/pubmed/37353495 http://dx.doi.org/10.1038/s41598-023-35912-z |
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