Cargando…

Conduit design with expanding diameter for enhanced flow

Conduits are commonly used for treating lesions in arteries and veins. The conventional stents are cylindrical in shape, which increases flow resistance with length. This study presents a design of stents and conduits where the conduit caliber expands gradually to reduce resistance while avoiding fl...

Descripción completa

Detalles Bibliográficos
Autores principales: Hashemi, Javad, Peeples, Hunter, Kuykendall, Riley, Raju, Seshadri, Kassab, Ghassan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290114/
https://www.ncbi.nlm.nih.gov/pubmed/37353535
http://dx.doi.org/10.1038/s41598-023-36165-6
_version_ 1785062422480945152
author Hashemi, Javad
Peeples, Hunter
Kuykendall, Riley
Raju, Seshadri
Kassab, Ghassan S.
author_facet Hashemi, Javad
Peeples, Hunter
Kuykendall, Riley
Raju, Seshadri
Kassab, Ghassan S.
author_sort Hashemi, Javad
collection PubMed
description Conduits are commonly used for treating lesions in arteries and veins. The conventional stents are cylindrical in shape, which increases flow resistance with length. This study presents a design of stents and conduits where the conduit caliber expands gradually to reduce resistance while avoiding flow separation. Inflow was provided from a header tank at two different pressures (i.e., 10 and 25 mm Hg pressure) into a cylindrical or expanding conduit. The initial conduit calibers were 2-, 3-, 4-, and 5-mm and 160-, 310-, and 620-mm lengths in each case. The flow rates of expanding caliber conduits (at a rate of r(4–6)/cm where r is the initial conduit radius) were compared to traditional cylindrical conduits of constant radius. The expanded caliber yields a significantly increased flow of 16–55% for R(4)/L expansion, 9–44% for R(5)/L expansion, and 1–28% for R(6)/L expansion. Simulated flow models using computational fluid dynamics (CFD) were used to validate and expand the experimental findings. Flow separation was detected for certain simulations by flow pathlines and wall shear stress (WSS) calculations. The results showed that a caliber expansion rate of r(6)/cm is the optimal rate of expansion for most potential applications with minimum flow separation, lower resistance, and increased flow.
format Online
Article
Text
id pubmed-10290114
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102901142023-06-25 Conduit design with expanding diameter for enhanced flow Hashemi, Javad Peeples, Hunter Kuykendall, Riley Raju, Seshadri Kassab, Ghassan S. Sci Rep Article Conduits are commonly used for treating lesions in arteries and veins. The conventional stents are cylindrical in shape, which increases flow resistance with length. This study presents a design of stents and conduits where the conduit caliber expands gradually to reduce resistance while avoiding flow separation. Inflow was provided from a header tank at two different pressures (i.e., 10 and 25 mm Hg pressure) into a cylindrical or expanding conduit. The initial conduit calibers were 2-, 3-, 4-, and 5-mm and 160-, 310-, and 620-mm lengths in each case. The flow rates of expanding caliber conduits (at a rate of r(4–6)/cm where r is the initial conduit radius) were compared to traditional cylindrical conduits of constant radius. The expanded caliber yields a significantly increased flow of 16–55% for R(4)/L expansion, 9–44% for R(5)/L expansion, and 1–28% for R(6)/L expansion. Simulated flow models using computational fluid dynamics (CFD) were used to validate and expand the experimental findings. Flow separation was detected for certain simulations by flow pathlines and wall shear stress (WSS) calculations. The results showed that a caliber expansion rate of r(6)/cm is the optimal rate of expansion for most potential applications with minimum flow separation, lower resistance, and increased flow. Nature Publishing Group UK 2023-06-23 /pmc/articles/PMC10290114/ /pubmed/37353535 http://dx.doi.org/10.1038/s41598-023-36165-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hashemi, Javad
Peeples, Hunter
Kuykendall, Riley
Raju, Seshadri
Kassab, Ghassan S.
Conduit design with expanding diameter for enhanced flow
title Conduit design with expanding diameter for enhanced flow
title_full Conduit design with expanding diameter for enhanced flow
title_fullStr Conduit design with expanding diameter for enhanced flow
title_full_unstemmed Conduit design with expanding diameter for enhanced flow
title_short Conduit design with expanding diameter for enhanced flow
title_sort conduit design with expanding diameter for enhanced flow
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290114/
https://www.ncbi.nlm.nih.gov/pubmed/37353535
http://dx.doi.org/10.1038/s41598-023-36165-6
work_keys_str_mv AT hashemijavad conduitdesignwithexpandingdiameterforenhancedflow
AT peepleshunter conduitdesignwithexpandingdiameterforenhancedflow
AT kuykendallriley conduitdesignwithexpandingdiameterforenhancedflow
AT rajuseshadri conduitdesignwithexpandingdiameterforenhancedflow
AT kassabghassans conduitdesignwithexpandingdiameterforenhancedflow