Molecular mechanism of phosphopeptide neoantigen immunogenicity

Altered protein phosphorylation in cancer cells often leads to surface presentation of phosphopeptide neoantigens. However, their role in cancer immunogenicity remains unclear. Here we describe a mechanism by which an HLA-B*0702-specific acute myeloid leukemia phosphoneoantigen, pMLL(747–755) (EPR(p...

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Detalles Bibliográficos
Autores principales: Patskovsky, Yury, Natarajan, Aswin, Patskovska, Larysa, Nyovanie, Samantha, Joshi, Bishnu, Morin, Benjamin, Brittsan, Christine, Huber, Olivia, Gordon, Samuel, Michelet, Xavier, Schmitzberger, Florian, Stein, Robert B., Findeis, Mark A., Hurwitz, Andy, Van Dijk, Marc, Chantzoura, Eleni, Yague, Alvaro S., Pollack Smith, Daniel, Buell, Jennifer S., Underwood, Dennis, Krogsgaard, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290117/
https://www.ncbi.nlm.nih.gov/pubmed/37353482
http://dx.doi.org/10.1038/s41467-023-39425-1

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