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Histone demethylases in the regulation of immunity and inflammation

Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl gro...

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Autores principales: Qu, Lihua, Yin, Tong, Zhao, Yijin, Lv, Wenting, Liu, Ziqi, Chen, Chao, Liu, Kejun, Shan, Shigang, Zhou, Rui, Li, Xiaoqing, Dong, Huifen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290154/
https://www.ncbi.nlm.nih.gov/pubmed/37353521
http://dx.doi.org/10.1038/s41420-023-01489-9
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author Qu, Lihua
Yin, Tong
Zhao, Yijin
Lv, Wenting
Liu, Ziqi
Chen, Chao
Liu, Kejun
Shan, Shigang
Zhou, Rui
Li, Xiaoqing
Dong, Huifen
author_facet Qu, Lihua
Yin, Tong
Zhao, Yijin
Lv, Wenting
Liu, Ziqi
Chen, Chao
Liu, Kejun
Shan, Shigang
Zhou, Rui
Li, Xiaoqing
Dong, Huifen
author_sort Qu, Lihua
collection PubMed
description Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases.
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spelling pubmed-102901542023-06-25 Histone demethylases in the regulation of immunity and inflammation Qu, Lihua Yin, Tong Zhao, Yijin Lv, Wenting Liu, Ziqi Chen, Chao Liu, Kejun Shan, Shigang Zhou, Rui Li, Xiaoqing Dong, Huifen Cell Death Discov Review Article Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases. Nature Publishing Group UK 2023-06-23 /pmc/articles/PMC10290154/ /pubmed/37353521 http://dx.doi.org/10.1038/s41420-023-01489-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Qu, Lihua
Yin, Tong
Zhao, Yijin
Lv, Wenting
Liu, Ziqi
Chen, Chao
Liu, Kejun
Shan, Shigang
Zhou, Rui
Li, Xiaoqing
Dong, Huifen
Histone demethylases in the regulation of immunity and inflammation
title Histone demethylases in the regulation of immunity and inflammation
title_full Histone demethylases in the regulation of immunity and inflammation
title_fullStr Histone demethylases in the regulation of immunity and inflammation
title_full_unstemmed Histone demethylases in the regulation of immunity and inflammation
title_short Histone demethylases in the regulation of immunity and inflammation
title_sort histone demethylases in the regulation of immunity and inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290154/
https://www.ncbi.nlm.nih.gov/pubmed/37353521
http://dx.doi.org/10.1038/s41420-023-01489-9
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