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Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults

IMPORTANCE: Spouses share common socioeconomic, environmental, and lifestyle factors, and multiple studies have found that spousal diabetes status was associated with diabetes prevalence. But the association of spousal diabetes status and ideal cardiovascular health metrics (ICVHMs) assessed by the...

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Autores principales: Zhao, Zhiyun, Cao, Qiuyu, Lu, Jieli, Lin, Hong, Gao, Zhengnan, Xu, Min, Xu, Yu, Wang, Tiange, Li, Mian, Chen, Yuhong, Wang, Shuangyuan, Zeng, Tianshu, Hu, Ruying, Yu, Xuefeng, Chen, Gang, Su, Qing, Mu, Yiming, Chen, Lulu, Tang, Xulei, Yan, Li, Qin, Guijun, Wan, Qin, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Qin, Yingfen, Chen, Li, Huo, Yanan, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Wu, Shengli, Yang, Tao, Deng, Huacong, Zhao, Jiajun, Shi, Lixin, Ning, Guang, Wang, Weiqing, Bi, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290251/
https://www.ncbi.nlm.nih.gov/pubmed/37351887
http://dx.doi.org/10.1001/jamanetworkopen.2023.19038
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author Zhao, Zhiyun
Cao, Qiuyu
Lu, Jieli
Lin, Hong
Gao, Zhengnan
Xu, Min
Xu, Yu
Wang, Tiange
Li, Mian
Chen, Yuhong
Wang, Shuangyuan
Zeng, Tianshu
Hu, Ruying
Yu, Xuefeng
Chen, Gang
Su, Qing
Mu, Yiming
Chen, Lulu
Tang, Xulei
Yan, Li
Qin, Guijun
Wan, Qin
Wang, Guixia
Shen, Feixia
Luo, Zuojie
Qin, Yingfen
Chen, Li
Huo, Yanan
Li, Qiang
Ye, Zhen
Zhang, Yinfei
Liu, Chao
Wang, Youmin
Wu, Shengli
Yang, Tao
Deng, Huacong
Zhao, Jiajun
Shi, Lixin
Ning, Guang
Wang, Weiqing
Bi, Yufang
author_facet Zhao, Zhiyun
Cao, Qiuyu
Lu, Jieli
Lin, Hong
Gao, Zhengnan
Xu, Min
Xu, Yu
Wang, Tiange
Li, Mian
Chen, Yuhong
Wang, Shuangyuan
Zeng, Tianshu
Hu, Ruying
Yu, Xuefeng
Chen, Gang
Su, Qing
Mu, Yiming
Chen, Lulu
Tang, Xulei
Yan, Li
Qin, Guijun
Wan, Qin
Wang, Guixia
Shen, Feixia
Luo, Zuojie
Qin, Yingfen
Chen, Li
Huo, Yanan
Li, Qiang
Ye, Zhen
Zhang, Yinfei
Liu, Chao
Wang, Youmin
Wu, Shengli
Yang, Tao
Deng, Huacong
Zhao, Jiajun
Shi, Lixin
Ning, Guang
Wang, Weiqing
Bi, Yufang
author_sort Zhao, Zhiyun
collection PubMed
description IMPORTANCE: Spouses share common socioeconomic, environmental, and lifestyle factors, and multiple studies have found that spousal diabetes status was associated with diabetes prevalence. But the association of spousal diabetes status and ideal cardiovascular health metrics (ICVHMs) assessed by the American Heart Association’s Life’s Essential 8 measures with incident diabetes has not been comprehensively characterized, especially in large-scale cohort studies. OBJECTIVE: To explore the association of spousal diabetes status and cardiovascular health metrics with risk of incident diabetes in Chinese adults. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included individuals in the China Cardiovascular Disease and Cancer Cohort without diabetes who underwent baseline and follow-up glucose measurements and had spouses with baseline glucose measurements. The data were collected in January 2011 to December 2012 and March 2014 to December 2016. The spousal study had a mean (SD) follow-up of 3.6 (0.9) years (median [IQR], 3.2 [2.9-4.5] years). Statistical analysis was performed from July to November 2022. EXPOSURE: Spousal diabetes status was diagnosed according to the 2010 American Diabetes Association (ADA) criteria. All participants provided detailed clinical, sociodemographic, and lifestyle information included in cardiovascular health metrics. MAIN OUTCOMES AND MEASURES: Incident diabetes, diagnosed according to 2010 ADA criteria. RESULTS: Overall, 34 821 individuals were included, with a mean (SD) age of 56.4 (8.3) years and 16 699 (48.0%) male participants. Spousal diabetes diagnosis was associated with an increased risk of incident diabetes (hazard ratio [HR], 1.15; 95% CI, 1.03-1.30). Furthermore, participants whose spouses had uncontrolled glycated hemoglobin (HbA(1c)) had a higher risk of diabetes (HR, 1.20; 95% CI, 1.04-1.39) but the risk of diabetes in participants whose spouses had controlled HbA(1c) did not increase significantly (HR, 1.10; 95% CI, 0.92-1.30). Moreover, this association varied with composite cardiovascular health status. Diabetes risk in individuals who had poor cardiovascular health status (<4 ICVHMs) was associated with spousal diabetes status (3 ICVHMs: HR, 1.50; 95% CI, 1.15-1.97), while diabetes risk in individuals who had intermediate to ideal cardiovascular health status (≥4 ICVHMs) was not associated with it (4 ICVHMs: HR, 1.01; 95% CI, 0.69-1.50). CONCLUSIONS AND RELEVANCE: In this study, spousal diabetes diagnosis with uncontrolled HbA(1c) level was associated with increased risk of incident diabetes, but strict management of spousal HbA(1c) level and improving ICVHM profiles may attenuate the association of spousal diabetes status with diabetes risk. These findings suggest the potential benefit of couple-based lifestyle or pharmaceutical interventions for diabetes.
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spelling pubmed-102902512023-06-25 Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults Zhao, Zhiyun Cao, Qiuyu Lu, Jieli Lin, Hong Gao, Zhengnan Xu, Min Xu, Yu Wang, Tiange Li, Mian Chen, Yuhong Wang, Shuangyuan Zeng, Tianshu Hu, Ruying Yu, Xuefeng Chen, Gang Su, Qing Mu, Yiming Chen, Lulu Tang, Xulei Yan, Li Qin, Guijun Wan, Qin Wang, Guixia Shen, Feixia Luo, Zuojie Qin, Yingfen Chen, Li Huo, Yanan Li, Qiang Ye, Zhen Zhang, Yinfei Liu, Chao Wang, Youmin Wu, Shengli Yang, Tao Deng, Huacong Zhao, Jiajun Shi, Lixin Ning, Guang Wang, Weiqing Bi, Yufang JAMA Netw Open Original Investigation IMPORTANCE: Spouses share common socioeconomic, environmental, and lifestyle factors, and multiple studies have found that spousal diabetes status was associated with diabetes prevalence. But the association of spousal diabetes status and ideal cardiovascular health metrics (ICVHMs) assessed by the American Heart Association’s Life’s Essential 8 measures with incident diabetes has not been comprehensively characterized, especially in large-scale cohort studies. OBJECTIVE: To explore the association of spousal diabetes status and cardiovascular health metrics with risk of incident diabetes in Chinese adults. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included individuals in the China Cardiovascular Disease and Cancer Cohort without diabetes who underwent baseline and follow-up glucose measurements and had spouses with baseline glucose measurements. The data were collected in January 2011 to December 2012 and March 2014 to December 2016. The spousal study had a mean (SD) follow-up of 3.6 (0.9) years (median [IQR], 3.2 [2.9-4.5] years). Statistical analysis was performed from July to November 2022. EXPOSURE: Spousal diabetes status was diagnosed according to the 2010 American Diabetes Association (ADA) criteria. All participants provided detailed clinical, sociodemographic, and lifestyle information included in cardiovascular health metrics. MAIN OUTCOMES AND MEASURES: Incident diabetes, diagnosed according to 2010 ADA criteria. RESULTS: Overall, 34 821 individuals were included, with a mean (SD) age of 56.4 (8.3) years and 16 699 (48.0%) male participants. Spousal diabetes diagnosis was associated with an increased risk of incident diabetes (hazard ratio [HR], 1.15; 95% CI, 1.03-1.30). Furthermore, participants whose spouses had uncontrolled glycated hemoglobin (HbA(1c)) had a higher risk of diabetes (HR, 1.20; 95% CI, 1.04-1.39) but the risk of diabetes in participants whose spouses had controlled HbA(1c) did not increase significantly (HR, 1.10; 95% CI, 0.92-1.30). Moreover, this association varied with composite cardiovascular health status. Diabetes risk in individuals who had poor cardiovascular health status (<4 ICVHMs) was associated with spousal diabetes status (3 ICVHMs: HR, 1.50; 95% CI, 1.15-1.97), while diabetes risk in individuals who had intermediate to ideal cardiovascular health status (≥4 ICVHMs) was not associated with it (4 ICVHMs: HR, 1.01; 95% CI, 0.69-1.50). CONCLUSIONS AND RELEVANCE: In this study, spousal diabetes diagnosis with uncontrolled HbA(1c) level was associated with increased risk of incident diabetes, but strict management of spousal HbA(1c) level and improving ICVHM profiles may attenuate the association of spousal diabetes status with diabetes risk. These findings suggest the potential benefit of couple-based lifestyle or pharmaceutical interventions for diabetes. American Medical Association 2023-06-23 /pmc/articles/PMC10290251/ /pubmed/37351887 http://dx.doi.org/10.1001/jamanetworkopen.2023.19038 Text en Copyright 2023 Zhao Z et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Zhao, Zhiyun
Cao, Qiuyu
Lu, Jieli
Lin, Hong
Gao, Zhengnan
Xu, Min
Xu, Yu
Wang, Tiange
Li, Mian
Chen, Yuhong
Wang, Shuangyuan
Zeng, Tianshu
Hu, Ruying
Yu, Xuefeng
Chen, Gang
Su, Qing
Mu, Yiming
Chen, Lulu
Tang, Xulei
Yan, Li
Qin, Guijun
Wan, Qin
Wang, Guixia
Shen, Feixia
Luo, Zuojie
Qin, Yingfen
Chen, Li
Huo, Yanan
Li, Qiang
Ye, Zhen
Zhang, Yinfei
Liu, Chao
Wang, Youmin
Wu, Shengli
Yang, Tao
Deng, Huacong
Zhao, Jiajun
Shi, Lixin
Ning, Guang
Wang, Weiqing
Bi, Yufang
Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title_full Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title_fullStr Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title_full_unstemmed Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title_short Association of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics With Risk of Incident Diabetes Among Chinese Adults
title_sort association of spousal diabetes status and ideal cardiovascular health metrics with risk of incident diabetes among chinese adults
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290251/
https://www.ncbi.nlm.nih.gov/pubmed/37351887
http://dx.doi.org/10.1001/jamanetworkopen.2023.19038
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