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Cerebral venous thrombosis (CVT) complicating tubercular meningitis

BACKGROUND: Tuberculous meningitis (TBM), complicated with cerebral venous thrombosis (CVT), has been sparsely reported and needs to be investigated further. METHODS: Among those with tuberculous meningitis in Haihe Hospital, Tianjin University, 3 patients with venous sinus thrombosis were identifie...

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Autores principales: Li, Qian, Han, Junfeng, Wang, Yiyi, Song, Yijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290308/
https://www.ncbi.nlm.nih.gov/pubmed/37355584
http://dx.doi.org/10.1186/s12883-023-03286-4
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author Li, Qian
Han, Junfeng
Wang, Yiyi
Song, Yijun
author_facet Li, Qian
Han, Junfeng
Wang, Yiyi
Song, Yijun
author_sort Li, Qian
collection PubMed
description BACKGROUND: Tuberculous meningitis (TBM), complicated with cerebral venous thrombosis (CVT), has been sparsely reported and needs to be investigated further. METHODS: Among those with tuberculous meningitis in Haihe Hospital, Tianjin University, 3 patients with venous sinus thrombosis were identified retrospectively. “Tuberculous meningitis” and “cerebral venous thrombosis” were used as keywords, and the retrieved literature was summarized and analyzed. Our data were combined with previously reported case data to describe this new condition. RESULTS: Among 28 patients with a median onset age of 31 years for TBM, 17 were females. The manifestations were fever, headache, and seizure. Magnetic resonance imaging (MRI) venography showed that the most common site of venous sinus thrombosis involved superior sagittal sinus, left transverse sinus, left sigmoid sinus, cavernous sinus, and straight sinus. The abnormalities found on MRI include hydrocephalus, exudates, hemorrhage, meningeal enhancement, infarction, and tuberculoma. In the acute phase, all patients received standard anti-TB treatment, and 14/28 patients received anticoagulant treatment. The mortality rate of these patients was 17.9%, and 21/28 (75%) became functionally independent. CONCLUSIONS: CVT is one of the rare complications of TMB and must be considered a differential diagnosis in patients with TBM who show poor clinical features and/or develop new neurological signs.
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spelling pubmed-102903082023-06-25 Cerebral venous thrombosis (CVT) complicating tubercular meningitis Li, Qian Han, Junfeng Wang, Yiyi Song, Yijun BMC Neurol Research BACKGROUND: Tuberculous meningitis (TBM), complicated with cerebral venous thrombosis (CVT), has been sparsely reported and needs to be investigated further. METHODS: Among those with tuberculous meningitis in Haihe Hospital, Tianjin University, 3 patients with venous sinus thrombosis were identified retrospectively. “Tuberculous meningitis” and “cerebral venous thrombosis” were used as keywords, and the retrieved literature was summarized and analyzed. Our data were combined with previously reported case data to describe this new condition. RESULTS: Among 28 patients with a median onset age of 31 years for TBM, 17 were females. The manifestations were fever, headache, and seizure. Magnetic resonance imaging (MRI) venography showed that the most common site of venous sinus thrombosis involved superior sagittal sinus, left transverse sinus, left sigmoid sinus, cavernous sinus, and straight sinus. The abnormalities found on MRI include hydrocephalus, exudates, hemorrhage, meningeal enhancement, infarction, and tuberculoma. In the acute phase, all patients received standard anti-TB treatment, and 14/28 patients received anticoagulant treatment. The mortality rate of these patients was 17.9%, and 21/28 (75%) became functionally independent. CONCLUSIONS: CVT is one of the rare complications of TMB and must be considered a differential diagnosis in patients with TBM who show poor clinical features and/or develop new neurological signs. BioMed Central 2023-06-24 /pmc/articles/PMC10290308/ /pubmed/37355584 http://dx.doi.org/10.1186/s12883-023-03286-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Qian
Han, Junfeng
Wang, Yiyi
Song, Yijun
Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title_full Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title_fullStr Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title_full_unstemmed Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title_short Cerebral venous thrombosis (CVT) complicating tubercular meningitis
title_sort cerebral venous thrombosis (cvt) complicating tubercular meningitis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290308/
https://www.ncbi.nlm.nih.gov/pubmed/37355584
http://dx.doi.org/10.1186/s12883-023-03286-4
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