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VarID2 quantifies gene expression noise dynamics and unveils functional heterogeneity of ageing hematopoietic stem cells

Variability of gene expression due to stochasticity of transcription or variation of extrinsic signals, termed biological noise, is a potential driving force of cellular differentiation. Utilizing single-cell RNA-sequencing, we develop VarID2 for the quantification of biological noise at single-cell...

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Detalles Bibliográficos
Autores principales:	Rosales-Alvarez, Reyna Edith, Rettkowski, Jasmin, Herman, Josip Stefan, Dumbović, Gabrijela, Cabezas-Wallscheid, Nina, Grün, Dominic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290360/ https://www.ncbi.nlm.nih.gov/pubmed/37353813 http://dx.doi.org/10.1186/s13059-023-02974-1

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