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Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature

BACKGROUND: Infection due to the SARS-CoV-2 virus can have a wide range of presentations from asymptomatic/mildly symptomatic to severe disease with multiorgan failure. Fever is a common symptom. But hyperpyrexia defined as temperature > 41.5 °C is not usual in COVID-19. CASE PRESENTATION: A 24-y...

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Autores principales: de Silva, Nipun Lakshitha, Fernando, Amitha, Wadanambi, Rohini, Niyas, A. R. J. P, Munasinghe, Nihal, Somasundaram, Gnani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290405/
https://www.ncbi.nlm.nih.gov/pubmed/37353853
http://dx.doi.org/10.1186/s13256-023-04008-7
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author de Silva, Nipun Lakshitha
Fernando, Amitha
Wadanambi, Rohini
Niyas, A. R. J. P
Munasinghe, Nihal
Somasundaram, Gnani
author_facet de Silva, Nipun Lakshitha
Fernando, Amitha
Wadanambi, Rohini
Niyas, A. R. J. P
Munasinghe, Nihal
Somasundaram, Gnani
author_sort de Silva, Nipun Lakshitha
collection PubMed
description BACKGROUND: Infection due to the SARS-CoV-2 virus can have a wide range of presentations from asymptomatic/mildly symptomatic to severe disease with multiorgan failure. Fever is a common symptom. But hyperpyrexia defined as temperature > 41.5 °C is not usual in COVID-19. CASE PRESENTATION: A 24-year-old previously well Sri Lankan female in the 24th week of gestation of her first pregnancy presented with fever and shortness of breath. She was confirmed to have coronavirus disease-2019 (COVID-19). History was suggestive of late presentation on approximately the eighth day of the illness. She had rapidly deteriorating hypoxia due to COVID pneumonia requiring mechanical ventilation two days after the admission. There was evidence of cytokine storm without any secondary bacterial infection. She received glucocorticoids, tocilizumab, and intravenous antibiotics. Although she initially showed mild improvements, she subsequently developed high-grade fever with the axillary temperature rising to 41.7 °C starting from the seventh day of admission. There were no causative medicines or risk factors to explain hyperpyrexia. She died on the ninth day of admission. CONCLUSIONS: There are no reports of patients developing this complication during pregnancy. The pathophysiology of this rare life-threatening complication remains elusive. Detailed reporting and in-depth analysis of such patients will facilitate the understanding of the associations and successful management of these patients.
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spelling pubmed-102904052023-06-25 Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature de Silva, Nipun Lakshitha Fernando, Amitha Wadanambi, Rohini Niyas, A. R. J. P Munasinghe, Nihal Somasundaram, Gnani J Med Case Rep Case Report BACKGROUND: Infection due to the SARS-CoV-2 virus can have a wide range of presentations from asymptomatic/mildly symptomatic to severe disease with multiorgan failure. Fever is a common symptom. But hyperpyrexia defined as temperature > 41.5 °C is not usual in COVID-19. CASE PRESENTATION: A 24-year-old previously well Sri Lankan female in the 24th week of gestation of her first pregnancy presented with fever and shortness of breath. She was confirmed to have coronavirus disease-2019 (COVID-19). History was suggestive of late presentation on approximately the eighth day of the illness. She had rapidly deteriorating hypoxia due to COVID pneumonia requiring mechanical ventilation two days after the admission. There was evidence of cytokine storm without any secondary bacterial infection. She received glucocorticoids, tocilizumab, and intravenous antibiotics. Although she initially showed mild improvements, she subsequently developed high-grade fever with the axillary temperature rising to 41.7 °C starting from the seventh day of admission. There were no causative medicines or risk factors to explain hyperpyrexia. She died on the ninth day of admission. CONCLUSIONS: There are no reports of patients developing this complication during pregnancy. The pathophysiology of this rare life-threatening complication remains elusive. Detailed reporting and in-depth analysis of such patients will facilitate the understanding of the associations and successful management of these patients. BioMed Central 2023-06-24 /pmc/articles/PMC10290405/ /pubmed/37353853 http://dx.doi.org/10.1186/s13256-023-04008-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
de Silva, Nipun Lakshitha
Fernando, Amitha
Wadanambi, Rohini
Niyas, A. R. J. P
Munasinghe, Nihal
Somasundaram, Gnani
Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title_full Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title_fullStr Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title_full_unstemmed Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title_short Hyperpyrexia in a previously healthy pregnant female with COVID pneumonia: a case report and review of the literature
title_sort hyperpyrexia in a previously healthy pregnant female with covid pneumonia: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290405/
https://www.ncbi.nlm.nih.gov/pubmed/37353853
http://dx.doi.org/10.1186/s13256-023-04008-7
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