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Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries
BACKGROUND: Oseltamivir is usually not often prescribed (or reimbursed) for non-high-risk patients consulting for influenza-like-illness (ILI) in primary care in Europe. We aimed to evaluate the cost-effectiveness of adding oseltamivir to usual primary care in adults/adolescents (13 years +) and chi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290610/ https://www.ncbi.nlm.nih.gov/pubmed/36131214 http://dx.doi.org/10.1007/s10198-022-01521-2 |
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author | Li, Xiao Bilcke, Joke van der Velden, Alike W. Bruyndonckx, Robin Coenen, Samuel Bongard, Emily de Paor, Muirrean Chlabicz, Slawomir Godycki-Cwirko, Maciek Francis, Nick Aabenhus, Rune Bucher, Heiner C. Colliers, Annelies De Sutter, An Garcia-Sangenis, Ana Glinz, Dominik Harbin, Nicolay J. Kosiek, Katarzyna Lindbæk, Morten Lionis, Christos Llor, Carl Mikó-Pauer, Réka Radzeviciene Jurgute, Ruta Seifert, Bohumil Sundvall, Pär-Daniel Touboul Lundgren, Pia Tsakountakis, Nikolaos Verheij, Theo J. Goossens, Herman Butler, Christopher C. Beutels, Philippe |
author_facet | Li, Xiao Bilcke, Joke van der Velden, Alike W. Bruyndonckx, Robin Coenen, Samuel Bongard, Emily de Paor, Muirrean Chlabicz, Slawomir Godycki-Cwirko, Maciek Francis, Nick Aabenhus, Rune Bucher, Heiner C. Colliers, Annelies De Sutter, An Garcia-Sangenis, Ana Glinz, Dominik Harbin, Nicolay J. Kosiek, Katarzyna Lindbæk, Morten Lionis, Christos Llor, Carl Mikó-Pauer, Réka Radzeviciene Jurgute, Ruta Seifert, Bohumil Sundvall, Pär-Daniel Touboul Lundgren, Pia Tsakountakis, Nikolaos Verheij, Theo J. Goossens, Herman Butler, Christopher C. Beutels, Philippe |
author_sort | Li, Xiao |
collection | PubMed |
description | BACKGROUND: Oseltamivir is usually not often prescribed (or reimbursed) for non-high-risk patients consulting for influenza-like-illness (ILI) in primary care in Europe. We aimed to evaluate the cost-effectiveness of adding oseltamivir to usual primary care in adults/adolescents (13 years +) and children with ILI during seasonal influenza epidemics, using data collected in an open-label, multi-season, randomised controlled trial of oseltamivir in 15 European countries. METHODS: Direct and indirect cost estimates were based on patient reported resource use and official country-specific unit costs. Health-Related Quality of Life was assessed by EQ-5D questionnaires. Costs and quality adjusted life-years (QALY) were bootstrapped (N = 10,000) to estimate incremental cost-effectiveness ratios (ICER), from both the healthcare payers’ and the societal perspectives, with uncertainty expressed through probabilistic sensitivity analysis and expected value for perfect information (EVPI) analysis. Additionally, scenario (self-reported spending), comorbidities subgroup and country-specific analyses were performed. RESULTS: The healthcare payers’ expected ICERs of oseltamivir were €22,459 per QALY gained in adults/adolescents and €13,001 in children. From the societal perspective, oseltamivir was cost-saving in adults/adolescents, but the ICER is €8,344 in children. Large uncertainties were observed in subgroups with comorbidities, especially for children. The expected ICERs and extent of decision uncertainty varied between countries (EVPI ranged €1–€35 per patient). CONCLUSION: Adding oseltamivir to primary usual care in Europe is likely to be cost-effective for treating adults/adolescents and children with ILI from the healthcare payers’ perspective (if willingness-to-pay per QALY gained > €22,459) and cost-saving in adults/adolescents from a societal perspective. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10198-022-01521-2. |
format | Online Article Text |
id | pubmed-10290610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-102906102023-06-26 Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries Li, Xiao Bilcke, Joke van der Velden, Alike W. Bruyndonckx, Robin Coenen, Samuel Bongard, Emily de Paor, Muirrean Chlabicz, Slawomir Godycki-Cwirko, Maciek Francis, Nick Aabenhus, Rune Bucher, Heiner C. Colliers, Annelies De Sutter, An Garcia-Sangenis, Ana Glinz, Dominik Harbin, Nicolay J. Kosiek, Katarzyna Lindbæk, Morten Lionis, Christos Llor, Carl Mikó-Pauer, Réka Radzeviciene Jurgute, Ruta Seifert, Bohumil Sundvall, Pär-Daniel Touboul Lundgren, Pia Tsakountakis, Nikolaos Verheij, Theo J. Goossens, Herman Butler, Christopher C. Beutels, Philippe Eur J Health Econ Original Paper BACKGROUND: Oseltamivir is usually not often prescribed (or reimbursed) for non-high-risk patients consulting for influenza-like-illness (ILI) in primary care in Europe. We aimed to evaluate the cost-effectiveness of adding oseltamivir to usual primary care in adults/adolescents (13 years +) and children with ILI during seasonal influenza epidemics, using data collected in an open-label, multi-season, randomised controlled trial of oseltamivir in 15 European countries. METHODS: Direct and indirect cost estimates were based on patient reported resource use and official country-specific unit costs. Health-Related Quality of Life was assessed by EQ-5D questionnaires. Costs and quality adjusted life-years (QALY) were bootstrapped (N = 10,000) to estimate incremental cost-effectiveness ratios (ICER), from both the healthcare payers’ and the societal perspectives, with uncertainty expressed through probabilistic sensitivity analysis and expected value for perfect information (EVPI) analysis. Additionally, scenario (self-reported spending), comorbidities subgroup and country-specific analyses were performed. RESULTS: The healthcare payers’ expected ICERs of oseltamivir were €22,459 per QALY gained in adults/adolescents and €13,001 in children. From the societal perspective, oseltamivir was cost-saving in adults/adolescents, but the ICER is €8,344 in children. Large uncertainties were observed in subgroups with comorbidities, especially for children. The expected ICERs and extent of decision uncertainty varied between countries (EVPI ranged €1–€35 per patient). CONCLUSION: Adding oseltamivir to primary usual care in Europe is likely to be cost-effective for treating adults/adolescents and children with ILI from the healthcare payers’ perspective (if willingness-to-pay per QALY gained > €22,459) and cost-saving in adults/adolescents from a societal perspective. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10198-022-01521-2. Springer Berlin Heidelberg 2022-09-22 2023 /pmc/articles/PMC10290610/ /pubmed/36131214 http://dx.doi.org/10.1007/s10198-022-01521-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Paper Li, Xiao Bilcke, Joke van der Velden, Alike W. Bruyndonckx, Robin Coenen, Samuel Bongard, Emily de Paor, Muirrean Chlabicz, Slawomir Godycki-Cwirko, Maciek Francis, Nick Aabenhus, Rune Bucher, Heiner C. Colliers, Annelies De Sutter, An Garcia-Sangenis, Ana Glinz, Dominik Harbin, Nicolay J. Kosiek, Katarzyna Lindbæk, Morten Lionis, Christos Llor, Carl Mikó-Pauer, Réka Radzeviciene Jurgute, Ruta Seifert, Bohumil Sundvall, Pär-Daniel Touboul Lundgren, Pia Tsakountakis, Nikolaos Verheij, Theo J. Goossens, Herman Butler, Christopher C. Beutels, Philippe Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title | Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title_full | Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title_fullStr | Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title_full_unstemmed | Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title_short | Cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled ALIC(4)E trial in 15 European countries |
title_sort | cost-effectiveness of adding oseltamivir to primary care for influenza-like-illness: economic evaluation alongside the randomised controlled alic(4)e trial in 15 european countries |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290610/ https://www.ncbi.nlm.nih.gov/pubmed/36131214 http://dx.doi.org/10.1007/s10198-022-01521-2 |
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