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Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site

γ-Secretase is an aspartyl intramembrane protease that cleaves the amyloid precursor protein (APP) involved in Alzheimer’s disease pathology and other transmembrane proteins. Substrate-bound structures reveal a stable hybrid β-sheet immediately following the substrate scissile bond consisting of β1...

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Detalles Bibliográficos
Autores principales:	Chen, Shu-Yu, Feilen, Lukas P., Chávez-Gutiérrez, Lucía, Steiner, Harald, Zacharias, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290658/ https://www.ncbi.nlm.nih.gov/pubmed/37355752 http://dx.doi.org/10.1038/s42003-023-05039-y

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