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Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients
BACKGROUND: The application of video‐assisted thoracoscopic surgery (VATS) for complex carina surgeries in treating non–small cell lung cancer (NSCLC) patients with involved carina is controversial. This study compared short‐ and medium‐term outcomes of VATS versus thoracotomy for carinal lung resec...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290917/ https://www.ncbi.nlm.nih.gov/pubmed/37127879 http://dx.doi.org/10.1111/1759-7714.14919 |
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author | Pan, Hanbo Zou, Ningyuan Huang, Jia Tian, Yu Jia, Yunxuan Zhu, Hongda Gu, Zenan Jiang, Long Yao, Feng Luo, Qingquan |
author_facet | Pan, Hanbo Zou, Ningyuan Huang, Jia Tian, Yu Jia, Yunxuan Zhu, Hongda Gu, Zenan Jiang, Long Yao, Feng Luo, Qingquan |
author_sort | Pan, Hanbo |
collection | PubMed |
description | BACKGROUND: The application of video‐assisted thoracoscopic surgery (VATS) for complex carina surgeries in treating non–small cell lung cancer (NSCLC) patients with involved carina is controversial. This study compared short‐ and medium‐term outcomes of VATS versus thoracotomy for carinal lung resection with carina reconstruction in treating locally advanced NSCLC, aiming to assess the potential benefit of VATS over thoracotomy for these patients. METHODS: A total of 37 consecutive NSCLC cases receiving VATS (n = 14) or thoracotomy (n = 23) for carinal lung resection with carina reconstruction from 2016 to 2021 were retrospectively identified. Baseline clinicopathological characteristics, perioperative outcomes, and survival profiles were investigated. RESULTS: Patients in the VATS and thoracotomy groups had comparable baseline clinicopathological characteristics (all p > 0.050). VATS decreased postoperative drainage volume compared with thoracotomy (1280 [1170–1510] vs. 1795 [1510–1905] mL, p = 0.012). Regarding surgical‐related pains, VATS reduced numeric rating scale scores on the postoperative day 1 (4 [3, 4] vs. 5 [4, 5], p = 0.021) and day 2 (3 [3, 4] vs. 5 [3–5], p = 0.023) than thoracotomy. No difference was found between the VATS and thoracotomy groups in other perioperative outcomes, postoperative complications, and assessment of lymph nodes (LNs) and LN stations (all p > 0.050). Moreover, patients in the two groups had comparable 3‐year disease‐free survival (DFS), overall survival (OS), and recurrence and mortality patterns. Further subgroup and Cox hazards regression analyses also observed no difference in DFS or OS between the two groups. CONCLUSIONS: VATS reduced postoperative drainage volume and ameliorated surgical‐related pain, and achieved comparable medium‐term survival compared to thoracotomy for carinal lung resection with carina reconstruction in treating locally advanced NSCLC. |
format | Online Article Text |
id | pubmed-10290917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons Australia, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-102909172023-06-27 Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients Pan, Hanbo Zou, Ningyuan Huang, Jia Tian, Yu Jia, Yunxuan Zhu, Hongda Gu, Zenan Jiang, Long Yao, Feng Luo, Qingquan Thorac Cancer Original Articles BACKGROUND: The application of video‐assisted thoracoscopic surgery (VATS) for complex carina surgeries in treating non–small cell lung cancer (NSCLC) patients with involved carina is controversial. This study compared short‐ and medium‐term outcomes of VATS versus thoracotomy for carinal lung resection with carina reconstruction in treating locally advanced NSCLC, aiming to assess the potential benefit of VATS over thoracotomy for these patients. METHODS: A total of 37 consecutive NSCLC cases receiving VATS (n = 14) or thoracotomy (n = 23) for carinal lung resection with carina reconstruction from 2016 to 2021 were retrospectively identified. Baseline clinicopathological characteristics, perioperative outcomes, and survival profiles were investigated. RESULTS: Patients in the VATS and thoracotomy groups had comparable baseline clinicopathological characteristics (all p > 0.050). VATS decreased postoperative drainage volume compared with thoracotomy (1280 [1170–1510] vs. 1795 [1510–1905] mL, p = 0.012). Regarding surgical‐related pains, VATS reduced numeric rating scale scores on the postoperative day 1 (4 [3, 4] vs. 5 [4, 5], p = 0.021) and day 2 (3 [3, 4] vs. 5 [3–5], p = 0.023) than thoracotomy. No difference was found between the VATS and thoracotomy groups in other perioperative outcomes, postoperative complications, and assessment of lymph nodes (LNs) and LN stations (all p > 0.050). Moreover, patients in the two groups had comparable 3‐year disease‐free survival (DFS), overall survival (OS), and recurrence and mortality patterns. Further subgroup and Cox hazards regression analyses also observed no difference in DFS or OS between the two groups. CONCLUSIONS: VATS reduced postoperative drainage volume and ameliorated surgical‐related pain, and achieved comparable medium‐term survival compared to thoracotomy for carinal lung resection with carina reconstruction in treating locally advanced NSCLC. John Wiley & Sons Australia, Ltd 2023-05-01 /pmc/articles/PMC10290917/ /pubmed/37127879 http://dx.doi.org/10.1111/1759-7714.14919 Text en © 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Pan, Hanbo Zou, Ningyuan Huang, Jia Tian, Yu Jia, Yunxuan Zhu, Hongda Gu, Zenan Jiang, Long Yao, Feng Luo, Qingquan Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title | Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title_full | Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title_fullStr | Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title_full_unstemmed | Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title_short | Short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
title_sort | short‐ and medium‐term outcomes of video‐assisted thoracoscopic surgery versus thoracotomy for carinal lung resection combined with carina reconstruction in locally advanced non–small cell lung cancer patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290917/ https://www.ncbi.nlm.nih.gov/pubmed/37127879 http://dx.doi.org/10.1111/1759-7714.14919 |
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