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Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)

BACKGROUND: Hepatocyte growth factor (HGF) is a cytokine linked to incident heart failure (HF), particularly HF with preserved ejection fraction (HFpEF). Increases in left ventricular (LV) mass and concentric remodelling defined by increasing mass-to-volume (M:V) ratios are imaging risk markers for...

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Autores principales: Ferraro, Richard A., Ogunmoroti, Oluseye, Zhao, Di, Ndumele, Chiadi E., Lima, Joao A.C., Varadarajan, Vinithra, Subramanya, Vinita, Pandey, Ambarish, Larson, Nicholas B., Bielinski, Suzette J., Michos, Erin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290945/
https://www.ncbi.nlm.nih.gov/pubmed/37377519
http://dx.doi.org/10.1016/j.cjco.2023.02.004
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author Ferraro, Richard A.
Ogunmoroti, Oluseye
Zhao, Di
Ndumele, Chiadi E.
Lima, Joao A.C.
Varadarajan, Vinithra
Subramanya, Vinita
Pandey, Ambarish
Larson, Nicholas B.
Bielinski, Suzette J.
Michos, Erin D.
author_facet Ferraro, Richard A.
Ogunmoroti, Oluseye
Zhao, Di
Ndumele, Chiadi E.
Lima, Joao A.C.
Varadarajan, Vinithra
Subramanya, Vinita
Pandey, Ambarish
Larson, Nicholas B.
Bielinski, Suzette J.
Michos, Erin D.
author_sort Ferraro, Richard A.
collection PubMed
description BACKGROUND: Hepatocyte growth factor (HGF) is a cytokine linked to incident heart failure (HF), particularly HF with preserved ejection fraction (HFpEF). Increases in left ventricular (LV) mass and concentric remodelling defined by increasing mass-to-volume (M:V) ratios are imaging risk markers for HFpEF. We aimed to determine if HGF is associated with adverse LV remodelling. METHODS: We studied 4907 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), free of cardiovascular disease and HF at baseline, who had HGF measured and cardiac magnetic resonance imaging (CMR) performed at baseline. Of these, 2921 completed a second CMR at 10 years. We examined the cross-sectional and longitudinal associations of HGF and LV structural parameters using multivariable-adjusted linear mixed-effect models, adjusting for cardiovascular disease risk factors and N-terminal pro B-type natriuretic peptide. RESULTS: The mean (SD) for age was 62 (10) years; 52% were female. Median (interquartile range) for HGF level was 890 pg/mL (745-1070). At baseline, the highest HGF tertile, compared to the lowest, was associated with a greater M:V ratio (relative difference 1.94 [95% confidence interval [CI]: 0.72, 3.17]) and lower LV end-diastolic volume (–2.07 mL [95% CI: –3.72, –0.42)]. In longitudinal analysis, the highest HGF tertile was associated with increasing M:V ratio (10-year difference: 4.68 [95% CI: 2.64, 6.72]) and decreasing LV end-diastolic volume (–4.74 [95% CI: –6.87, –2.62]). CONCLUSIONS: In a community-based cohort, higher HGF levels were independently associated with a concentric LV remodelling pattern of increasing M:V ratio and decreasing LV end-diastolic volume by CMR over 10 years. These associations may reflect an intermediate phenotype explaining the association of HGF with HFpEF risk.
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spelling pubmed-102909452023-06-27 Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA) Ferraro, Richard A. Ogunmoroti, Oluseye Zhao, Di Ndumele, Chiadi E. Lima, Joao A.C. Varadarajan, Vinithra Subramanya, Vinita Pandey, Ambarish Larson, Nicholas B. Bielinski, Suzette J. Michos, Erin D. CJC Open Original Article BACKGROUND: Hepatocyte growth factor (HGF) is a cytokine linked to incident heart failure (HF), particularly HF with preserved ejection fraction (HFpEF). Increases in left ventricular (LV) mass and concentric remodelling defined by increasing mass-to-volume (M:V) ratios are imaging risk markers for HFpEF. We aimed to determine if HGF is associated with adverse LV remodelling. METHODS: We studied 4907 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), free of cardiovascular disease and HF at baseline, who had HGF measured and cardiac magnetic resonance imaging (CMR) performed at baseline. Of these, 2921 completed a second CMR at 10 years. We examined the cross-sectional and longitudinal associations of HGF and LV structural parameters using multivariable-adjusted linear mixed-effect models, adjusting for cardiovascular disease risk factors and N-terminal pro B-type natriuretic peptide. RESULTS: The mean (SD) for age was 62 (10) years; 52% were female. Median (interquartile range) for HGF level was 890 pg/mL (745-1070). At baseline, the highest HGF tertile, compared to the lowest, was associated with a greater M:V ratio (relative difference 1.94 [95% confidence interval [CI]: 0.72, 3.17]) and lower LV end-diastolic volume (–2.07 mL [95% CI: –3.72, –0.42)]. In longitudinal analysis, the highest HGF tertile was associated with increasing M:V ratio (10-year difference: 4.68 [95% CI: 2.64, 6.72]) and decreasing LV end-diastolic volume (–4.74 [95% CI: –6.87, –2.62]). CONCLUSIONS: In a community-based cohort, higher HGF levels were independently associated with a concentric LV remodelling pattern of increasing M:V ratio and decreasing LV end-diastolic volume by CMR over 10 years. These associations may reflect an intermediate phenotype explaining the association of HGF with HFpEF risk. Elsevier 2023-02-19 /pmc/articles/PMC10290945/ /pubmed/37377519 http://dx.doi.org/10.1016/j.cjco.2023.02.004 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ferraro, Richard A.
Ogunmoroti, Oluseye
Zhao, Di
Ndumele, Chiadi E.
Lima, Joao A.C.
Varadarajan, Vinithra
Subramanya, Vinita
Pandey, Ambarish
Larson, Nicholas B.
Bielinski, Suzette J.
Michos, Erin D.
Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title_full Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title_fullStr Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title_full_unstemmed Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title_short Hepatocyte Growth Factor and 10-Year Change in Left Ventricular Structure: The Multi-Ethnic Study of Atherosclerosis (MESA)
title_sort hepatocyte growth factor and 10-year change in left ventricular structure: the multi-ethnic study of atherosclerosis (mesa)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290945/
https://www.ncbi.nlm.nih.gov/pubmed/37377519
http://dx.doi.org/10.1016/j.cjco.2023.02.004
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