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Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism
Circular dichroism (CD) spectroscopy has been widely demonstrated for detecting chiral molecules. However, the determination of chiral mixtures with various concentrations and enantiomeric ratios can be a challenging task. To solve this problem, we report an enhanced vibrational circular dichroism (...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290984/ https://www.ncbi.nlm.nih.gov/pubmed/37357238 http://dx.doi.org/10.1038/s41377-023-01186-3 |
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author | Xu, Cheng Ren, Zhihao Zhou, Hong Zhou, Jingkai Ho, Chong Pei Wang, Nan Lee, Chengkuo |
author_facet | Xu, Cheng Ren, Zhihao Zhou, Hong Zhou, Jingkai Ho, Chong Pei Wang, Nan Lee, Chengkuo |
author_sort | Xu, Cheng |
collection | PubMed |
description | Circular dichroism (CD) spectroscopy has been widely demonstrated for detecting chiral molecules. However, the determination of chiral mixtures with various concentrations and enantiomeric ratios can be a challenging task. To solve this problem, we report an enhanced vibrational circular dichroism (VCD) sensing platform based on plasmonic chiral metamaterials, which presents a 6-magnitude signal enhancement with a selectivity of chiral molecules. Guided by coupled-mode theory, we leverage both in-plane and out-of-plane symmetry-breaking structures for chiral metamaterial design enabled by a two-step lithography process, which increases the near-field coupling strengths and varies the ratio between absorption and radiation loss, resulting in improved chiral light-matter interaction and enhanced molecular VCD signals. Besides, we demonstrate the thin-film sensing process of BSA and β-lactoglobulin proteins, which contain secondary structures α-helix and β-sheet and achieve a limit of detection down to zeptomole level. Furthermore, we also, for the first time, explore the potential of enhanced VCD spectroscopy by demonstrating a selective sensing process of chiral mixtures, where the mixing ratio can be successfully differentiated with our proposed chiral metamaterials. Our findings improve the sensing signal of molecules and expand the extractable information, paving the way toward label-free, compact, small-volume chiral molecule detection for stereochemical and clinical diagnosis applications. |
format | Online Article Text |
id | pubmed-10290984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-102909842023-06-27 Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism Xu, Cheng Ren, Zhihao Zhou, Hong Zhou, Jingkai Ho, Chong Pei Wang, Nan Lee, Chengkuo Light Sci Appl Article Circular dichroism (CD) spectroscopy has been widely demonstrated for detecting chiral molecules. However, the determination of chiral mixtures with various concentrations and enantiomeric ratios can be a challenging task. To solve this problem, we report an enhanced vibrational circular dichroism (VCD) sensing platform based on plasmonic chiral metamaterials, which presents a 6-magnitude signal enhancement with a selectivity of chiral molecules. Guided by coupled-mode theory, we leverage both in-plane and out-of-plane symmetry-breaking structures for chiral metamaterial design enabled by a two-step lithography process, which increases the near-field coupling strengths and varies the ratio between absorption and radiation loss, resulting in improved chiral light-matter interaction and enhanced molecular VCD signals. Besides, we demonstrate the thin-film sensing process of BSA and β-lactoglobulin proteins, which contain secondary structures α-helix and β-sheet and achieve a limit of detection down to zeptomole level. Furthermore, we also, for the first time, explore the potential of enhanced VCD spectroscopy by demonstrating a selective sensing process of chiral mixtures, where the mixing ratio can be successfully differentiated with our proposed chiral metamaterials. Our findings improve the sensing signal of molecules and expand the extractable information, paving the way toward label-free, compact, small-volume chiral molecule detection for stereochemical and clinical diagnosis applications. Nature Publishing Group UK 2023-06-25 /pmc/articles/PMC10290984/ /pubmed/37357238 http://dx.doi.org/10.1038/s41377-023-01186-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Xu, Cheng Ren, Zhihao Zhou, Hong Zhou, Jingkai Ho, Chong Pei Wang, Nan Lee, Chengkuo Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title | Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title_full | Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title_fullStr | Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title_full_unstemmed | Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title_short | Expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
title_sort | expanding chiral metamaterials for retrieving fingerprints via vibrational circular dichroism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10290984/ https://www.ncbi.nlm.nih.gov/pubmed/37357238 http://dx.doi.org/10.1038/s41377-023-01186-3 |
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