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The central inflammatory regulator IκBζ: induction, regulation and physiological functions
IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291074/ https://www.ncbi.nlm.nih.gov/pubmed/37377955 http://dx.doi.org/10.3389/fimmu.2023.1188253 |
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author | Feng, Yanpeng Chen, Zhiyuan Xu, Yi Han, Yuxuan Jia, Xiujuan Wang, Zixuan Zhang, Nannan Lv, Wenjing |
author_facet | Feng, Yanpeng Chen, Zhiyuan Xu, Yi Han, Yuxuan Jia, Xiujuan Wang, Zixuan Zhang, Nannan Lv, Wenjing |
author_sort | Feng, Yanpeng |
collection | PubMed |
description | IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases. |
format | Online Article Text |
id | pubmed-10291074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102910742023-06-27 The central inflammatory regulator IκBζ: induction, regulation and physiological functions Feng, Yanpeng Chen, Zhiyuan Xu, Yi Han, Yuxuan Jia, Xiujuan Wang, Zixuan Zhang, Nannan Lv, Wenjing Front Immunol Immunology IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291074/ /pubmed/37377955 http://dx.doi.org/10.3389/fimmu.2023.1188253 Text en Copyright © 2023 Feng, Chen, Xu, Han, Jia, Wang, Zhang and Lv https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Feng, Yanpeng Chen, Zhiyuan Xu, Yi Han, Yuxuan Jia, Xiujuan Wang, Zixuan Zhang, Nannan Lv, Wenjing The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title | The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title_full | The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title_fullStr | The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title_full_unstemmed | The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title_short | The central inflammatory regulator IκBζ: induction, regulation and physiological functions |
title_sort | central inflammatory regulator iκbζ: induction, regulation and physiological functions |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291074/ https://www.ncbi.nlm.nih.gov/pubmed/37377955 http://dx.doi.org/10.3389/fimmu.2023.1188253 |
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