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The central inflammatory regulator IκBζ: induction, regulation and physiological functions

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors...

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Autores principales: Feng, Yanpeng, Chen, Zhiyuan, Xu, Yi, Han, Yuxuan, Jia, Xiujuan, Wang, Zixuan, Zhang, Nannan, Lv, Wenjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291074/
https://www.ncbi.nlm.nih.gov/pubmed/37377955
http://dx.doi.org/10.3389/fimmu.2023.1188253
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author Feng, Yanpeng
Chen, Zhiyuan
Xu, Yi
Han, Yuxuan
Jia, Xiujuan
Wang, Zixuan
Zhang, Nannan
Lv, Wenjing
author_facet Feng, Yanpeng
Chen, Zhiyuan
Xu, Yi
Han, Yuxuan
Jia, Xiujuan
Wang, Zixuan
Zhang, Nannan
Lv, Wenjing
author_sort Feng, Yanpeng
collection PubMed
description IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases.
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spelling pubmed-102910742023-06-27 The central inflammatory regulator IκBζ: induction, regulation and physiological functions Feng, Yanpeng Chen, Zhiyuan Xu, Yi Han, Yuxuan Jia, Xiujuan Wang, Zixuan Zhang, Nannan Lv, Wenjing Front Immunol Immunology IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies because of its role in inflammation. Specifically, it is a key gene in the regulation of a variety of inflammatory factors in the NF-KB pathway, thereby affecting the progression of related diseases. In recent years, investigations into NFKBIZ have led to greater understanding of this gene. In this review, we summarize the induction of NFKBIZ and then elucidate its transcription, translation, molecular mechanism and physiological function. Finally, the roles played by NFKBIZ in psoriasis, cancer, kidney injury, autoimmune diseases and other diseases are described. NFKBIZ functions are universal and bidirectional, and therefore, this gene may exert a great influence on the regulation of inflammation and inflammation-related diseases. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291074/ /pubmed/37377955 http://dx.doi.org/10.3389/fimmu.2023.1188253 Text en Copyright © 2023 Feng, Chen, Xu, Han, Jia, Wang, Zhang and Lv https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Feng, Yanpeng
Chen, Zhiyuan
Xu, Yi
Han, Yuxuan
Jia, Xiujuan
Wang, Zixuan
Zhang, Nannan
Lv, Wenjing
The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title_full The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title_fullStr The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title_full_unstemmed The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title_short The central inflammatory regulator IκBζ: induction, regulation and physiological functions
title_sort central inflammatory regulator iκbζ: induction, regulation and physiological functions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291074/
https://www.ncbi.nlm.nih.gov/pubmed/37377955
http://dx.doi.org/10.3389/fimmu.2023.1188253
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