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OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea

INTRODUCTION: Primary dysmenorrhea (PDM) is a common condition among women of reproductive age, characterized by menstrual pain in the absence of any organic causes. Previous research has established a link between the A118G polymorphism in the mu-opioid receptor (OPRM1) gene and pain experience in...

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Autores principales: Hsu, Pei-Shan, Cheng, Chou-Ming, Chao, Hsiang-Tai, Lin, Ming-Wei, Li, Wei-Chi, Lee, Lin-Chien, Liu, Ching-Hsiung, Chen, Li-Fen, Hsieh, Jen-Chuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291086/
https://www.ncbi.nlm.nih.gov/pubmed/37378013
http://dx.doi.org/10.3389/fnins.2023.1179851
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author Hsu, Pei-Shan
Cheng, Chou-Ming
Chao, Hsiang-Tai
Lin, Ming-Wei
Li, Wei-Chi
Lee, Lin-Chien
Liu, Ching-Hsiung
Chen, Li-Fen
Hsieh, Jen-Chuen
author_facet Hsu, Pei-Shan
Cheng, Chou-Ming
Chao, Hsiang-Tai
Lin, Ming-Wei
Li, Wei-Chi
Lee, Lin-Chien
Liu, Ching-Hsiung
Chen, Li-Fen
Hsieh, Jen-Chuen
author_sort Hsu, Pei-Shan
collection PubMed
description INTRODUCTION: Primary dysmenorrhea (PDM) is a common condition among women of reproductive age, characterized by menstrual pain in the absence of any organic causes. Previous research has established a link between the A118G polymorphism in the mu-opioid receptor (OPRM1) gene and pain experience in PDM. Specifically, carriers of the G allele have been found to exhibit maladaptive functional connectivity between the descending pain modulatory system and the motor system in young women with PDM. This study aims to explore the potential relationship between the OPRM1 A118G polymorphism and changes in white matter in young women with PDM. METHODS: The study enrolled 43 individuals with PDM, including 13 AA homozygotes and 30 G allele carriers. Diffusion tensor imaging (DTI) scans were performed during both the menstrual and peri-ovulatory phases, and tract-based spatial statistics (TBSS) and probabilistic tractography were used to explore variations in white matter microstructure related to the OPRM1 A118G polymorphism. The short-form McGill Pain Questionnaire (MPQ) was used to access participants’ pain experience during the MEN phase. RESULTS: Two-way ANOVA on TBSS analysis revealed a significant main effect of genotype, with no phase effect or phase-gene interaction detected. Planned contrast analysis showed that during the menstrual phase, G allele carriers had higher fractional anisotropy (FA) and lower radial diffusivity in the corpus callosum and the left corona radiata compared to AA homozygotes. Tractographic analysis indicated the involvement of the left internal capsule, left corticospinal tract, and bilateral medial motor cortex. Additionally, the mean FA of the corpus callosum and the corona radiata was negatively correlated with MPQ scales in AA homozygotes, but this correlation was not observed in G allele carriers. No significant genotype difference was found during the pain-free peri-ovulary phase. DISCUSSION: OPRM1 A118G polymorphism may influence the connection between structural integrity and dysmenorrheic pain, where the G allele could impede the pain-regulating effects of the A allele. These novel findings shed light on the underlying mechanisms of both adaptive and maladaptive structural neuroplasticity in PDM, depending on the specific OPRM1 polymorphism.
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spelling pubmed-102910862023-06-27 OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea Hsu, Pei-Shan Cheng, Chou-Ming Chao, Hsiang-Tai Lin, Ming-Wei Li, Wei-Chi Lee, Lin-Chien Liu, Ching-Hsiung Chen, Li-Fen Hsieh, Jen-Chuen Front Neurosci Neuroscience INTRODUCTION: Primary dysmenorrhea (PDM) is a common condition among women of reproductive age, characterized by menstrual pain in the absence of any organic causes. Previous research has established a link between the A118G polymorphism in the mu-opioid receptor (OPRM1) gene and pain experience in PDM. Specifically, carriers of the G allele have been found to exhibit maladaptive functional connectivity between the descending pain modulatory system and the motor system in young women with PDM. This study aims to explore the potential relationship between the OPRM1 A118G polymorphism and changes in white matter in young women with PDM. METHODS: The study enrolled 43 individuals with PDM, including 13 AA homozygotes and 30 G allele carriers. Diffusion tensor imaging (DTI) scans were performed during both the menstrual and peri-ovulatory phases, and tract-based spatial statistics (TBSS) and probabilistic tractography were used to explore variations in white matter microstructure related to the OPRM1 A118G polymorphism. The short-form McGill Pain Questionnaire (MPQ) was used to access participants’ pain experience during the MEN phase. RESULTS: Two-way ANOVA on TBSS analysis revealed a significant main effect of genotype, with no phase effect or phase-gene interaction detected. Planned contrast analysis showed that during the menstrual phase, G allele carriers had higher fractional anisotropy (FA) and lower radial diffusivity in the corpus callosum and the left corona radiata compared to AA homozygotes. Tractographic analysis indicated the involvement of the left internal capsule, left corticospinal tract, and bilateral medial motor cortex. Additionally, the mean FA of the corpus callosum and the corona radiata was negatively correlated with MPQ scales in AA homozygotes, but this correlation was not observed in G allele carriers. No significant genotype difference was found during the pain-free peri-ovulary phase. DISCUSSION: OPRM1 A118G polymorphism may influence the connection between structural integrity and dysmenorrheic pain, where the G allele could impede the pain-regulating effects of the A allele. These novel findings shed light on the underlying mechanisms of both adaptive and maladaptive structural neuroplasticity in PDM, depending on the specific OPRM1 polymorphism. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291086/ /pubmed/37378013 http://dx.doi.org/10.3389/fnins.2023.1179851 Text en Copyright © 2023 Hsu, Cheng, Chao, Lin, Li, Lee, Liu, Chen and Hsieh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hsu, Pei-Shan
Cheng, Chou-Ming
Chao, Hsiang-Tai
Lin, Ming-Wei
Li, Wei-Chi
Lee, Lin-Chien
Liu, Ching-Hsiung
Chen, Li-Fen
Hsieh, Jen-Chuen
OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title_full OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title_fullStr OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title_full_unstemmed OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title_short OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
title_sort oprm1 a118g polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291086/
https://www.ncbi.nlm.nih.gov/pubmed/37378013
http://dx.doi.org/10.3389/fnins.2023.1179851
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