Activation of the microglial P2X7R/NLRP3 inflammasome mediates central sensitization in a mouse model of medication overuse headache

BACKGROUND: Excessive use of headache treatments often leads to the development, progression and exacerbation of primary headache, which is defined as medication overuse headache (MOH). A significant pathophysiological mechanism of MOH is central sensitization. Recent evidence suggests that central...

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Detalles Bibliográficos
Autores principales: Wang, Yanyun, Dong, Liang, Zhang, Yun, Zhang, Yixin, Qin, Guangcheng, Zhang, Dunke, Chen, Lixue, He, Wei, Zhou, Jiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291138/
https://www.ncbi.nlm.nih.gov/pubmed/37377770
http://dx.doi.org/10.3389/fnmol.2023.1177171

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