Nerve trunk healing and neuroma formation after nerve transection injury

The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is s...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Dong-Xu, Yang, Ming-Xi, Jiang, Zhen-Min, Chen, Miao, Chang, Kun, Zhan, Yong-Xin, Gong, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291201/
https://www.ncbi.nlm.nih.gov/pubmed/37377855
http://dx.doi.org/10.3389/fneur.2023.1184246
_version_ 1785062645661958144
author Huang, Dong-Xu
Yang, Ming-Xi
Jiang, Zhen-Min
Chen, Miao
Chang, Kun
Zhan, Yong-Xin
Gong, Xu
author_facet Huang, Dong-Xu
Yang, Ming-Xi
Jiang, Zhen-Min
Chen, Miao
Chang, Kun
Zhan, Yong-Xin
Gong, Xu
author_sort Huang, Dong-Xu
collection PubMed
description The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is sufficient and necessary for nerve fiber regeneration. Angiogenesis and nerve fiber regeneration reveal a positive correlation in the early time. Scarring and nerve fiber regeneration show a negative correlation in the late phase. We hypothesize that anti-angiogenesis suppresses neuromas. Subsequently, we provide potential protocols to test our hypothesis. Finally, we recommend employing anti-angiogenic small-molecule protein kinase inhibitors to investigate nerve transection injuries.
format Online
Article
Text
id pubmed-10291201
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102912012023-06-27 Nerve trunk healing and neuroma formation after nerve transection injury Huang, Dong-Xu Yang, Ming-Xi Jiang, Zhen-Min Chen, Miao Chang, Kun Zhan, Yong-Xin Gong, Xu Front Neurol Neurology The nerve trunk healing process of a transected peripheral nerve trunk is composed of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation probably share identical molecular mediators and similar regulations. At the nerve transection site, angiogenesis is sufficient and necessary for nerve fiber regeneration. Angiogenesis and nerve fiber regeneration reveal a positive correlation in the early time. Scarring and nerve fiber regeneration show a negative correlation in the late phase. We hypothesize that anti-angiogenesis suppresses neuromas. Subsequently, we provide potential protocols to test our hypothesis. Finally, we recommend employing anti-angiogenic small-molecule protein kinase inhibitors to investigate nerve transection injuries. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291201/ /pubmed/37377855 http://dx.doi.org/10.3389/fneur.2023.1184246 Text en Copyright © 2023 Huang, Yang, Jiang, Chen, Chang, Zhan and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Huang, Dong-Xu
Yang, Ming-Xi
Jiang, Zhen-Min
Chen, Miao
Chang, Kun
Zhan, Yong-Xin
Gong, Xu
Nerve trunk healing and neuroma formation after nerve transection injury
title Nerve trunk healing and neuroma formation after nerve transection injury
title_full Nerve trunk healing and neuroma formation after nerve transection injury
title_fullStr Nerve trunk healing and neuroma formation after nerve transection injury
title_full_unstemmed Nerve trunk healing and neuroma formation after nerve transection injury
title_short Nerve trunk healing and neuroma formation after nerve transection injury
title_sort nerve trunk healing and neuroma formation after nerve transection injury
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291201/
https://www.ncbi.nlm.nih.gov/pubmed/37377855
http://dx.doi.org/10.3389/fneur.2023.1184246
work_keys_str_mv AT huangdongxu nervetrunkhealingandneuromaformationafternervetransectioninjury
AT yangmingxi nervetrunkhealingandneuromaformationafternervetransectioninjury
AT jiangzhenmin nervetrunkhealingandneuromaformationafternervetransectioninjury
AT chenmiao nervetrunkhealingandneuromaformationafternervetransectioninjury
AT changkun nervetrunkhealingandneuromaformationafternervetransectioninjury
AT zhanyongxin nervetrunkhealingandneuromaformationafternervetransectioninjury
AT gongxu nervetrunkhealingandneuromaformationafternervetransectioninjury

Ejemplares similares