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The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing

Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level. These two functions are ensured by crucial events such as homologous chromosomal pairing, synapsis, re...

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Detalles Bibliográficos
Autores principales: Solé, Mireia, Pascual, Álvaro, Anton, Ester, Blanco, Joan, Sarrate, Zaida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291267/
https://www.ncbi.nlm.nih.gov/pubmed/37377734
http://dx.doi.org/10.3389/fcell.2023.1191156
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author Solé, Mireia
Pascual, Álvaro
Anton, Ester
Blanco, Joan
Sarrate, Zaida
author_facet Solé, Mireia
Pascual, Álvaro
Anton, Ester
Blanco, Joan
Sarrate, Zaida
author_sort Solé, Mireia
collection PubMed
description Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level. These two functions are ensured by crucial events such as homologous chromosomal pairing, synapsis, recombination and segregation. In most sexually reproducing eukaryotes, homologous chromosome pairing depends on a set of mechanisms, some of them associated with the repair of DNA double-strand breaks (DSBs) induced at the onset of prophase I, and others that operate before DSBs formation. In this article, we will review various strategies utilised by model organisms for DSB-independent pairing. Specifically, we will focus on mechanisms such as chromosome clustering, nuclear and chromosome movements, as well as the involvement of specific proteins, non-coding RNA, and DNA sequences.
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spelling pubmed-102912672023-06-27 The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing Solé, Mireia Pascual, Álvaro Anton, Ester Blanco, Joan Sarrate, Zaida Front Cell Dev Biol Cell and Developmental Biology Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level. These two functions are ensured by crucial events such as homologous chromosomal pairing, synapsis, recombination and segregation. In most sexually reproducing eukaryotes, homologous chromosome pairing depends on a set of mechanisms, some of them associated with the repair of DNA double-strand breaks (DSBs) induced at the onset of prophase I, and others that operate before DSBs formation. In this article, we will review various strategies utilised by model organisms for DSB-independent pairing. Specifically, we will focus on mechanisms such as chromosome clustering, nuclear and chromosome movements, as well as the involvement of specific proteins, non-coding RNA, and DNA sequences. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291267/ /pubmed/37377734 http://dx.doi.org/10.3389/fcell.2023.1191156 Text en Copyright © 2023 Solé, Pascual, Anton, Blanco and Sarrate. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Solé, Mireia
Pascual, Álvaro
Anton, Ester
Blanco, Joan
Sarrate, Zaida
The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title_full The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title_fullStr The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title_full_unstemmed The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title_short The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing
title_sort courtship choreography of homologous chromosomes: timing and mechanisms of dsb-independent pairing
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291267/
https://www.ncbi.nlm.nih.gov/pubmed/37377734
http://dx.doi.org/10.3389/fcell.2023.1191156
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