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Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study

OBJECTIVE: The association between Helicobacter pylori and hypertension is unclear. Herein, we aimed to investigate the association between H. pylori and hypertension among adults in Sudan. METHODS: We conducted a community-based case–control study (175 participants in each arm) in the Wad Hamid dis...

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Autores principales: Hassan, Ahmed A, Ahmed, Bashir E, Osman, Osman E, Adam, Ishag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291417/
https://www.ncbi.nlm.nih.gov/pubmed/37350309
http://dx.doi.org/10.1177/03000605231182545
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author Hassan, Ahmed A
Ahmed, Bashir E
Osman, Osman E
Adam, Ishag
author_facet Hassan, Ahmed A
Ahmed, Bashir E
Osman, Osman E
Adam, Ishag
author_sort Hassan, Ahmed A
collection PubMed
description OBJECTIVE: The association between Helicobacter pylori and hypertension is unclear. Herein, we aimed to investigate the association between H. pylori and hypertension among adults in Sudan. METHODS: We conducted a community-based case–control study (175 participants in each arm) in the Wad Hamid district in northern Sudan. Cases comprised adults with hypertension and controls were non-hypertensive adults. We assessed participants' data using a questionnaire. We also conducted rapid H. pylori antibody tests and binary and linear regression analyses. RESULTS: Multivariable logistic regression revealed age (adjusted odds ratio [AOR] 1.05, 95% confidence interval [CI] 1.03–1.07), female sex (AOR 5.50, 95% CI 2.36–12.80), and body mass index (AOR 1.12, 95% CI 1.07–1.17) were significantly associated with hypertension. Moreover, compared with controls, a significantly higher number of patients with hypertension were positive for H. pylori (82/175, 46.9% vs. 46/175, 26.3%). H. pylori seropositivity was associated with systolic blood pressure (coefficient 3.811), diastolic blood pressure (coefficient 3.492), mean blood pressure (coefficient 3.599), and hypertension (AOR 3.15, 95% CI 1.82–5.46). CONCLUSION: Our study revealed a significant positive association between H. pylori seropositivity and hypertension. This finding supports literature recommending the eradication of H. pylori to prevent hypertension and its complications.
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spelling pubmed-102914172023-06-27 Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study Hassan, Ahmed A Ahmed, Bashir E Osman, Osman E Adam, Ishag J Int Med Res Prospective Clinical Research Report OBJECTIVE: The association between Helicobacter pylori and hypertension is unclear. Herein, we aimed to investigate the association between H. pylori and hypertension among adults in Sudan. METHODS: We conducted a community-based case–control study (175 participants in each arm) in the Wad Hamid district in northern Sudan. Cases comprised adults with hypertension and controls were non-hypertensive adults. We assessed participants' data using a questionnaire. We also conducted rapid H. pylori antibody tests and binary and linear regression analyses. RESULTS: Multivariable logistic regression revealed age (adjusted odds ratio [AOR] 1.05, 95% confidence interval [CI] 1.03–1.07), female sex (AOR 5.50, 95% CI 2.36–12.80), and body mass index (AOR 1.12, 95% CI 1.07–1.17) were significantly associated with hypertension. Moreover, compared with controls, a significantly higher number of patients with hypertension were positive for H. pylori (82/175, 46.9% vs. 46/175, 26.3%). H. pylori seropositivity was associated with systolic blood pressure (coefficient 3.811), diastolic blood pressure (coefficient 3.492), mean blood pressure (coefficient 3.599), and hypertension (AOR 3.15, 95% CI 1.82–5.46). CONCLUSION: Our study revealed a significant positive association between H. pylori seropositivity and hypertension. This finding supports literature recommending the eradication of H. pylori to prevent hypertension and its complications. SAGE Publications 2023-06-23 /pmc/articles/PMC10291417/ /pubmed/37350309 http://dx.doi.org/10.1177/03000605231182545 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospective Clinical Research Report
Hassan, Ahmed A
Ahmed, Bashir E
Osman, Osman E
Adam, Ishag
Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title_full Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title_fullStr Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title_full_unstemmed Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title_short Association between Helicobacter pylori seropositivity and hypertension among adults in Northern Sudan: a community-based case–control study
title_sort association between helicobacter pylori seropositivity and hypertension among adults in northern sudan: a community-based case–control study
topic Prospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291417/
https://www.ncbi.nlm.nih.gov/pubmed/37350309
http://dx.doi.org/10.1177/03000605231182545
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