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Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study

OBJECTIVES: Periodontitis disproportionately affects different racial and ethnic populations. We have previously reported the higher levels of Porphyromonas gingivalis and lower ratios of Streptococcus cristatus to P. gingivalis may contribute to periodontal health disparities. This prospective coho...

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Autores principales: Wang, Bing-Yan, Burgardt, Grayson, Parthasarathy, Kavitha, Ho, Daniel K., Weltman, Robin L., Tribble, Gena D., Hong, Jianming, Cron, Stanley, Xie, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291508/
https://www.ncbi.nlm.nih.gov/pubmed/37377523
http://dx.doi.org/10.3389/froh.2023.1212728
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author Wang, Bing-Yan
Burgardt, Grayson
Parthasarathy, Kavitha
Ho, Daniel K.
Weltman, Robin L.
Tribble, Gena D.
Hong, Jianming
Cron, Stanley
Xie, Hua
author_facet Wang, Bing-Yan
Burgardt, Grayson
Parthasarathy, Kavitha
Ho, Daniel K.
Weltman, Robin L.
Tribble, Gena D.
Hong, Jianming
Cron, Stanley
Xie, Hua
author_sort Wang, Bing-Yan
collection PubMed
description OBJECTIVES: Periodontitis disproportionately affects different racial and ethnic populations. We have previously reported the higher levels of Porphyromonas gingivalis and lower ratios of Streptococcus cristatus to P. gingivalis may contribute to periodontal health disparities. This prospective cohort study was designed to investigate if ethnic/racial groups responded differently to non-surgical periodontal treatment and if the treatment outcomes correlated to the bacterial distribution in patients with periodontitis before treatment. METHODS: This prospective cohort pilot study was carried out in an academic setting, at the School of Dentistry, University of Texas Health Science Center at Houston. Dental plaque was collected from a total of 75 African Americans, Caucasians and Hispanics periodontitis patients in a 3-year period. Quantitation of P. gingivalis and S. cristatus was carried out using qPCR. Clinical parameters including probing depths and clinical attachment levels were determined before and after nonsurgical treatment. Data were analyzed using one-way ANOVA, the Kruskal–Wallis test, the paired samples t-test and the chi-square test. RESULTS: The gains in clinical attachment levels after treatment significantly differed amongst the 3 groups–Caucasians responded most favorably, followed by African-Americans, lastly Hispanics, while numbers of P. gingivalis were highest in Hispanics, followed by African-Americans, and lowest in Caucasians (p = 0.015). However, no statistical differences were found in the numbers of S. cristatus amongst the 3 groups. CONCLUSION: Differential response to nonsurgical periodontal treatment and distribution of P. gingivalis are present in different ethnic/racial groups with periodontitis.
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spelling pubmed-102915082023-06-27 Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study Wang, Bing-Yan Burgardt, Grayson Parthasarathy, Kavitha Ho, Daniel K. Weltman, Robin L. Tribble, Gena D. Hong, Jianming Cron, Stanley Xie, Hua Front Oral Health Oral Health OBJECTIVES: Periodontitis disproportionately affects different racial and ethnic populations. We have previously reported the higher levels of Porphyromonas gingivalis and lower ratios of Streptococcus cristatus to P. gingivalis may contribute to periodontal health disparities. This prospective cohort study was designed to investigate if ethnic/racial groups responded differently to non-surgical periodontal treatment and if the treatment outcomes correlated to the bacterial distribution in patients with periodontitis before treatment. METHODS: This prospective cohort pilot study was carried out in an academic setting, at the School of Dentistry, University of Texas Health Science Center at Houston. Dental plaque was collected from a total of 75 African Americans, Caucasians and Hispanics periodontitis patients in a 3-year period. Quantitation of P. gingivalis and S. cristatus was carried out using qPCR. Clinical parameters including probing depths and clinical attachment levels were determined before and after nonsurgical treatment. Data were analyzed using one-way ANOVA, the Kruskal–Wallis test, the paired samples t-test and the chi-square test. RESULTS: The gains in clinical attachment levels after treatment significantly differed amongst the 3 groups–Caucasians responded most favorably, followed by African-Americans, lastly Hispanics, while numbers of P. gingivalis were highest in Hispanics, followed by African-Americans, and lowest in Caucasians (p = 0.015). However, no statistical differences were found in the numbers of S. cristatus amongst the 3 groups. CONCLUSION: Differential response to nonsurgical periodontal treatment and distribution of P. gingivalis are present in different ethnic/racial groups with periodontitis. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10291508/ /pubmed/37377523 http://dx.doi.org/10.3389/froh.2023.1212728 Text en © 2023 Wang, Burgardt, Parthasarathy, Ho, Weltman, Tribble, Hong, Cron and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Wang, Bing-Yan
Burgardt, Grayson
Parthasarathy, Kavitha
Ho, Daniel K.
Weltman, Robin L.
Tribble, Gena D.
Hong, Jianming
Cron, Stanley
Xie, Hua
Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title_full Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title_fullStr Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title_full_unstemmed Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title_short Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
title_sort influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291508/
https://www.ncbi.nlm.nih.gov/pubmed/37377523
http://dx.doi.org/10.3389/froh.2023.1212728
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