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An epigenetic signature of advanced colorectal cancer metastasis

Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival. Ear...

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Autores principales: Rodger, Euan J., Gimenez, Gregory, Ajithkumar, Priyadarshana, Stockwell, Peter A., Almomani, Suzan, Bowden, Sarah A., Leichter, Anna L., Ahn, Antonio, Pattison, Sharon, McCall, John L., Schmeier, Sebastian, Frizelle, Frank A., Eccles, Michael R., Purcell, Rachel V., Chatterjee, Aniruddha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291510/
https://www.ncbi.nlm.nih.gov/pubmed/37378317
http://dx.doi.org/10.1016/j.isci.2023.106986
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author Rodger, Euan J.
Gimenez, Gregory
Ajithkumar, Priyadarshana
Stockwell, Peter A.
Almomani, Suzan
Bowden, Sarah A.
Leichter, Anna L.
Ahn, Antonio
Pattison, Sharon
McCall, John L.
Schmeier, Sebastian
Frizelle, Frank A.
Eccles, Michael R.
Purcell, Rachel V.
Chatterjee, Aniruddha
author_facet Rodger, Euan J.
Gimenez, Gregory
Ajithkumar, Priyadarshana
Stockwell, Peter A.
Almomani, Suzan
Bowden, Sarah A.
Leichter, Anna L.
Ahn, Antonio
Pattison, Sharon
McCall, John L.
Schmeier, Sebastian
Frizelle, Frank A.
Eccles, Michael R.
Purcell, Rachel V.
Chatterjee, Aniruddha
author_sort Rodger, Euan J.
collection PubMed
description Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival. Earlier detection and a better understanding of molecular drivers for CRC metastasis are of critical clinical importance. Here, we identify a signature of advanced CRC metastasis by performing whole genome-scale DNA methylation and full transcriptome analyses of paired primary cancers and liver metastases from CRC patients. We observed striking methylation differences between primary and metastatic pairs. A subset of loci showed coordinated methylation-expression changes, suggesting these are potentially epigenetic drivers that control the expression of critical genes in the metastatic cascade. The identification of CRC epigenomic markers of metastasis has the potential to enable better outcome prediction and lead to the discovery of new therapeutic targets.
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spelling pubmed-102915102023-06-27 An epigenetic signature of advanced colorectal cancer metastasis Rodger, Euan J. Gimenez, Gregory Ajithkumar, Priyadarshana Stockwell, Peter A. Almomani, Suzan Bowden, Sarah A. Leichter, Anna L. Ahn, Antonio Pattison, Sharon McCall, John L. Schmeier, Sebastian Frizelle, Frank A. Eccles, Michael R. Purcell, Rachel V. Chatterjee, Aniruddha iScience Article Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival. Earlier detection and a better understanding of molecular drivers for CRC metastasis are of critical clinical importance. Here, we identify a signature of advanced CRC metastasis by performing whole genome-scale DNA methylation and full transcriptome analyses of paired primary cancers and liver metastases from CRC patients. We observed striking methylation differences between primary and metastatic pairs. A subset of loci showed coordinated methylation-expression changes, suggesting these are potentially epigenetic drivers that control the expression of critical genes in the metastatic cascade. The identification of CRC epigenomic markers of metastasis has the potential to enable better outcome prediction and lead to the discovery of new therapeutic targets. Elsevier 2023-05-28 /pmc/articles/PMC10291510/ /pubmed/37378317 http://dx.doi.org/10.1016/j.isci.2023.106986 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rodger, Euan J.
Gimenez, Gregory
Ajithkumar, Priyadarshana
Stockwell, Peter A.
Almomani, Suzan
Bowden, Sarah A.
Leichter, Anna L.
Ahn, Antonio
Pattison, Sharon
McCall, John L.
Schmeier, Sebastian
Frizelle, Frank A.
Eccles, Michael R.
Purcell, Rachel V.
Chatterjee, Aniruddha
An epigenetic signature of advanced colorectal cancer metastasis
title An epigenetic signature of advanced colorectal cancer metastasis
title_full An epigenetic signature of advanced colorectal cancer metastasis
title_fullStr An epigenetic signature of advanced colorectal cancer metastasis
title_full_unstemmed An epigenetic signature of advanced colorectal cancer metastasis
title_short An epigenetic signature of advanced colorectal cancer metastasis
title_sort epigenetic signature of advanced colorectal cancer metastasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291510/
https://www.ncbi.nlm.nih.gov/pubmed/37378317
http://dx.doi.org/10.1016/j.isci.2023.106986
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