Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist

[Image: see text] We have recently reported on the use of aryl-fluorosulfates in designing water- and plasma-stable agents that covalently target Lys, Tyr, or His residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. Here, we report further structural, cellular, and pha...

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Detalles Bibliográficos
Autores principales: Udompholkul, Parima, Garza-Granados, Ana, Alboreggia, Giulia, Baggio, Carlo, McGuire, Jack, Pegan, Scott D., Pellecchia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291551/
https://www.ncbi.nlm.nih.gov/pubmed/37262387
http://dx.doi.org/10.1021/acs.jmedchem.3c00467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291551/
https://www.ncbi.nlm.nih.gov/pubmed/37262387
http://dx.doi.org/10.1021/acs.jmedchem.3c00467

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