Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc

While it is well known that mechanical signals can either promote or disrupt intervertebral disc (IVD) homeostasis, the molecular mechanisms for transducing mechanical stimuli are not fully understood. The transient receptor potential vanilloid 4 (TRPV4) ion channel activated in isolated IVD cells i...

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Detalles Bibliográficos
Autores principales: Easson, Garrett W. D., Savadipour, Alireza, Anandarajah, Akila, Iannucci, Leanne E., Lake, Spencer P., Guilak, Farshid, Tang, Simon Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291737/
https://www.ncbi.nlm.nih.gov/pubmed/36583692
http://dx.doi.org/10.1096/fj.202201388R

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