Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

Mostrar otras versiones (1)

BACKGROUND: Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance, holds promise as a potential therapeutic approa...

Descripción completa

Detalles Bibliográficos
Autores principales: Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L., Thomas, Neal J., Grunwell, Jocelyn R., Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N., Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R., Walley, Keith R., Standage, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291783/
https://www.ncbi.nlm.nih.gov/pubmed/37365661
http://dx.doi.org/10.1186/s13054-023-04535-1

Ejemplares similares

Ejemplares similares