Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes

An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as the sole solvent. This reaction proceeded under air, tolerated a wide range of functional-groups and was easily scaled up. Bioactive natural products like indrili...

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Detalles Bibliográficos
Autores principales: Wei, Dong, Lu, Han-Yu, Miao, Han-Zhe, Feng, Chen-Guo, Lin, Guo-Qiang, Liu, Yingbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291873/
https://www.ncbi.nlm.nih.gov/pubmed/37377870
http://dx.doi.org/10.1039/d3ra03510g
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author Wei, Dong
Lu, Han-Yu
Miao, Han-Zhe
Feng, Chen-Guo
Lin, Guo-Qiang
Liu, Yingbin
author_facet Wei, Dong
Lu, Han-Yu
Miao, Han-Zhe
Feng, Chen-Guo
Lin, Guo-Qiang
Liu, Yingbin
author_sort Wei, Dong
collection PubMed
description An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as the sole solvent. This reaction proceeded under air, tolerated a wide range of functional-groups and was easily scaled up. Bioactive natural products like indriline were synthesized via the developed protocol. Preliminary results demonstrate that the enantioselective variant can also be achieved.
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spelling pubmed-102918732023-06-27 Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes Wei, Dong Lu, Han-Yu Miao, Han-Zhe Feng, Chen-Guo Lin, Guo-Qiang Liu, Yingbin RSC Adv Chemistry An efficient and environmentally benign method for the preparation of substituted indene derivatives has been developed by using water as the sole solvent. This reaction proceeded under air, tolerated a wide range of functional-groups and was easily scaled up. Bioactive natural products like indriline were synthesized via the developed protocol. Preliminary results demonstrate that the enantioselective variant can also be achieved. The Royal Society of Chemistry 2023-06-26 /pmc/articles/PMC10291873/ /pubmed/37377870 http://dx.doi.org/10.1039/d3ra03510g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wei, Dong
Lu, Han-Yu
Miao, Han-Zhe
Feng, Chen-Guo
Lin, Guo-Qiang
Liu, Yingbin
Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title_full Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title_fullStr Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title_full_unstemmed Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title_short Pd-catalyzed intermolecular consecutive double Heck reaction “on water” under air: facile synthesis of substituted indenes
title_sort pd-catalyzed intermolecular consecutive double heck reaction “on water” under air: facile synthesis of substituted indenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291873/
https://www.ncbi.nlm.nih.gov/pubmed/37377870
http://dx.doi.org/10.1039/d3ra03510g
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