High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature

Current literature suggests an increased incidence of rhabdomyolysis in patients with chronic liver disease (CLD) compared to the general population. We present a case of a 60-year-old female with a history of non-alcoholic fatty liver disease and cirrhosis who developed rhabdomyolysis and acute kid...

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Autores principales: Gudiwada, Mohan Chandra Vinay Bharadwaj, Gaddam, Vinuthna, Rahman, Maheen, Jasti, Jaswanth R, Bhalodia, Paritaben, Jitta, Sahas Reddy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292103/
https://www.ncbi.nlm.nih.gov/pubmed/37378115
http://dx.doi.org/10.7759/cureus.39150
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author Gudiwada, Mohan Chandra Vinay Bharadwaj
Gaddam, Vinuthna
Rahman, Maheen
Jasti, Jaswanth R
Bhalodia, Paritaben
Jitta, Sahas Reddy
author_facet Gudiwada, Mohan Chandra Vinay Bharadwaj
Gaddam, Vinuthna
Rahman, Maheen
Jasti, Jaswanth R
Bhalodia, Paritaben
Jitta, Sahas Reddy
author_sort Gudiwada, Mohan Chandra Vinay Bharadwaj
collection PubMed
description Current literature suggests an increased incidence of rhabdomyolysis in patients with chronic liver disease (CLD) compared to the general population. We present a case of a 60-year-old female with a history of non-alcoholic fatty liver disease and cirrhosis who developed rhabdomyolysis and acute kidney injury after starting high-intensity atorvastatin therapy. This case highlights the potential risks associated with high-intensity statin therapy in patients with CLD, particularly those with advanced liver dysfunction, emphasizing the need for cautious prescribing and thorough risk-benefit assessment in this vulnerable patient population.
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spelling pubmed-102921032023-06-27 High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature Gudiwada, Mohan Chandra Vinay Bharadwaj Gaddam, Vinuthna Rahman, Maheen Jasti, Jaswanth R Bhalodia, Paritaben Jitta, Sahas Reddy Cureus Cardiology Current literature suggests an increased incidence of rhabdomyolysis in patients with chronic liver disease (CLD) compared to the general population. We present a case of a 60-year-old female with a history of non-alcoholic fatty liver disease and cirrhosis who developed rhabdomyolysis and acute kidney injury after starting high-intensity atorvastatin therapy. This case highlights the potential risks associated with high-intensity statin therapy in patients with CLD, particularly those with advanced liver dysfunction, emphasizing the need for cautious prescribing and thorough risk-benefit assessment in this vulnerable patient population. Cureus 2023-05-17 /pmc/articles/PMC10292103/ /pubmed/37378115 http://dx.doi.org/10.7759/cureus.39150 Text en Copyright © 2023, Gudiwada et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Gudiwada, Mohan Chandra Vinay Bharadwaj
Gaddam, Vinuthna
Rahman, Maheen
Jasti, Jaswanth R
Bhalodia, Paritaben
Jitta, Sahas Reddy
High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title_full High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title_fullStr High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title_full_unstemmed High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title_short High-Intensity Statin Therapy and Associated Rhabdomyolysis in Chronic Liver Disease: A Case Report and Review of Literature
title_sort high-intensity statin therapy and associated rhabdomyolysis in chronic liver disease: a case report and review of literature
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292103/
https://www.ncbi.nlm.nih.gov/pubmed/37378115
http://dx.doi.org/10.7759/cureus.39150
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