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Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir

In 2018, data from a surveillance study in Botswana evaluating adverse birth outcomes raised concerns that women on antiretroviral therapy (ART) containing dolutegravir (DTG) may be at increased risk for neural tube defects (NTDs). The mechanism of action for DTG involves chelation of Mg(2+) ions in...

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Detalles Bibliográficos
Autores principales:	Gelineau-van Waes, J., van Waes, M. A., Hallgren, J., Hulen, J., Bredehoeft, M., Ashley-Koch, A. E., Krupp, D., Gregory, S. G., Stessman, H. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292217/ https://www.ncbi.nlm.nih.gov/pubmed/37377737 http://dx.doi.org/10.3389/fcell.2023.1175917

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