Long non-coding RNAs in intracerebral hemorrhage
Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292654/ https://www.ncbi.nlm.nih.gov/pubmed/37377769 http://dx.doi.org/10.3389/fnmol.2023.1119275 |
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author | Zhang, Chenyu Zhang, Ying Wang, Qi Fang, Zhenwei Xu, Xinyi Zhao, Mengnan Xu, Ting |
author_facet | Zhang, Chenyu Zhang, Ying Wang, Qi Fang, Zhenwei Xu, Xinyi Zhao, Mengnan Xu, Ting |
author_sort | Zhang, Chenyu |
collection | PubMed |
description | Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more than 200 nt without translational activity. As a vital class of diverse molecules, lncRNAs are involved in developmental and pathological processes and have been attractive for decades. LncRNAs have also become potential targets for therapies, as they were massively identified and profiled. In particular, emerging evidence has revealed the critical role of lncRNAs in ICH while attempts were made to treat ICH via regulating lncRNAs. But the latest evidence remains to be summarized. Thus, in this review, we will summarize the recent advances in lncRNA in ICH, highlighting the regulatory role of lncRNAs and their potential as therapeutic targets. |
format | Online Article Text |
id | pubmed-10292654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102926542023-06-27 Long non-coding RNAs in intracerebral hemorrhage Zhang, Chenyu Zhang, Ying Wang, Qi Fang, Zhenwei Xu, Xinyi Zhao, Mengnan Xu, Ting Front Mol Neurosci Molecular Neuroscience Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more than 200 nt without translational activity. As a vital class of diverse molecules, lncRNAs are involved in developmental and pathological processes and have been attractive for decades. LncRNAs have also become potential targets for therapies, as they were massively identified and profiled. In particular, emerging evidence has revealed the critical role of lncRNAs in ICH while attempts were made to treat ICH via regulating lncRNAs. But the latest evidence remains to be summarized. Thus, in this review, we will summarize the recent advances in lncRNA in ICH, highlighting the regulatory role of lncRNAs and their potential as therapeutic targets. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10292654/ /pubmed/37377769 http://dx.doi.org/10.3389/fnmol.2023.1119275 Text en Copyright © 2023 Zhang, Zhang, Wang, Fang, Xu, Zhao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Zhang, Chenyu Zhang, Ying Wang, Qi Fang, Zhenwei Xu, Xinyi Zhao, Mengnan Xu, Ting Long non-coding RNAs in intracerebral hemorrhage |
title | Long non-coding RNAs in intracerebral hemorrhage |
title_full | Long non-coding RNAs in intracerebral hemorrhage |
title_fullStr | Long non-coding RNAs in intracerebral hemorrhage |
title_full_unstemmed | Long non-coding RNAs in intracerebral hemorrhage |
title_short | Long non-coding RNAs in intracerebral hemorrhage |
title_sort | long non-coding rnas in intracerebral hemorrhage |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292654/ https://www.ncbi.nlm.nih.gov/pubmed/37377769 http://dx.doi.org/10.3389/fnmol.2023.1119275 |
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