Long non-coding RNAs in intracerebral hemorrhage

Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more t...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Chenyu, Zhang, Ying, Wang, Qi, Fang, Zhenwei, Xu, Xinyi, Zhao, Mengnan, Xu, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292654/
https://www.ncbi.nlm.nih.gov/pubmed/37377769
http://dx.doi.org/10.3389/fnmol.2023.1119275
_version_ 1785062863455387648
author Zhang, Chenyu
Zhang, Ying
Wang, Qi
Fang, Zhenwei
Xu, Xinyi
Zhao, Mengnan
Xu, Ting
author_facet Zhang, Chenyu
Zhang, Ying
Wang, Qi
Fang, Zhenwei
Xu, Xinyi
Zhao, Mengnan
Xu, Ting
author_sort Zhang, Chenyu
collection PubMed
description Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more than 200 nt without translational activity. As a vital class of diverse molecules, lncRNAs are involved in developmental and pathological processes and have been attractive for decades. LncRNAs have also become potential targets for therapies, as they were massively identified and profiled. In particular, emerging evidence has revealed the critical role of lncRNAs in ICH while attempts were made to treat ICH via regulating lncRNAs. But the latest evidence remains to be summarized. Thus, in this review, we will summarize the recent advances in lncRNA in ICH, highlighting the regulatory role of lncRNAs and their potential as therapeutic targets.
format Online
Article
Text
id pubmed-10292654
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-102926542023-06-27 Long non-coding RNAs in intracerebral hemorrhage Zhang, Chenyu Zhang, Ying Wang, Qi Fang, Zhenwei Xu, Xinyi Zhao, Mengnan Xu, Ting Front Mol Neurosci Molecular Neuroscience Intracerebral hemorrhage (ICH), a subtype of stroke, can lead to long-term disability and is one of the leading causes of death. Unfortunately, the effectiveness of pharmacological therapy for ICH is still uncertain. Long non-coding RNA (lncRNA) was defined as an RNA molecule that consists of more than 200 nt without translational activity. As a vital class of diverse molecules, lncRNAs are involved in developmental and pathological processes and have been attractive for decades. LncRNAs have also become potential targets for therapies, as they were massively identified and profiled. In particular, emerging evidence has revealed the critical role of lncRNAs in ICH while attempts were made to treat ICH via regulating lncRNAs. But the latest evidence remains to be summarized. Thus, in this review, we will summarize the recent advances in lncRNA in ICH, highlighting the regulatory role of lncRNAs and their potential as therapeutic targets. Frontiers Media S.A. 2023-06-12 /pmc/articles/PMC10292654/ /pubmed/37377769 http://dx.doi.org/10.3389/fnmol.2023.1119275 Text en Copyright © 2023 Zhang, Zhang, Wang, Fang, Xu, Zhao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Zhang, Chenyu
Zhang, Ying
Wang, Qi
Fang, Zhenwei
Xu, Xinyi
Zhao, Mengnan
Xu, Ting
Long non-coding RNAs in intracerebral hemorrhage
title Long non-coding RNAs in intracerebral hemorrhage
title_full Long non-coding RNAs in intracerebral hemorrhage
title_fullStr Long non-coding RNAs in intracerebral hemorrhage
title_full_unstemmed Long non-coding RNAs in intracerebral hemorrhage
title_short Long non-coding RNAs in intracerebral hemorrhage
title_sort long non-coding rnas in intracerebral hemorrhage
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292654/
https://www.ncbi.nlm.nih.gov/pubmed/37377769
http://dx.doi.org/10.3389/fnmol.2023.1119275
work_keys_str_mv AT zhangchenyu longnoncodingrnasinintracerebralhemorrhage
AT zhangying longnoncodingrnasinintracerebralhemorrhage
AT wangqi longnoncodingrnasinintracerebralhemorrhage
AT fangzhenwei longnoncodingrnasinintracerebralhemorrhage
AT xuxinyi longnoncodingrnasinintracerebralhemorrhage
AT zhaomengnan longnoncodingrnasinintracerebralhemorrhage
AT xuting longnoncodingrnasinintracerebralhemorrhage