Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Septic shock is when initial fluid resuscitation fails to increase the mean atrial pressure to greater than or equal to 65 mm Hg. The 2021 Surviving Sepsis Campaign guidelines recommend corticoster...

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Autores principales: Aldhaeefi, Mohammed, Alshaya, Abdulrahman, Belrhiti, Sanaa, Rungkitwattanakul, Dhakrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292733/
https://www.ncbi.nlm.nih.gov/pubmed/37378083
http://dx.doi.org/10.1097/CCE.0000000000000940
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author Aldhaeefi, Mohammed
Alshaya, Abdulrahman
Belrhiti, Sanaa
Rungkitwattanakul, Dhakrit
author_facet Aldhaeefi, Mohammed
Alshaya, Abdulrahman
Belrhiti, Sanaa
Rungkitwattanakul, Dhakrit
author_sort Aldhaeefi, Mohammed
collection PubMed
description Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Septic shock is when initial fluid resuscitation fails to increase the mean atrial pressure to greater than or equal to 65 mm Hg. The 2021 Surviving Sepsis Campaign guidelines recommend corticosteroids for vasopressor and fluid-refractory septic shock patients. Medication shortages can arise, and their etiologies include natural disasters, quality control issues, and manufacturing discontinuation. The U.S. Food and Drug Administration and the American Society of Health-System Pharmacists announced a shortage of IV hydrocortisone. Methylprednisolone and dexamethasone are considered therapeutic alternatives to hydrocortisone. This commentary aims to guide clinicians on the alternative to hydrocortisone among septic shock patients due to medication shortage.
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spelling pubmed-102927332023-06-27 Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage Aldhaeefi, Mohammed Alshaya, Abdulrahman Belrhiti, Sanaa Rungkitwattanakul, Dhakrit Crit Care Explor Commentary Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Septic shock is when initial fluid resuscitation fails to increase the mean atrial pressure to greater than or equal to 65 mm Hg. The 2021 Surviving Sepsis Campaign guidelines recommend corticosteroids for vasopressor and fluid-refractory septic shock patients. Medication shortages can arise, and their etiologies include natural disasters, quality control issues, and manufacturing discontinuation. The U.S. Food and Drug Administration and the American Society of Health-System Pharmacists announced a shortage of IV hydrocortisone. Methylprednisolone and dexamethasone are considered therapeutic alternatives to hydrocortisone. This commentary aims to guide clinicians on the alternative to hydrocortisone among septic shock patients due to medication shortage. Lippincott Williams & Wilkins 2023-06-23 /pmc/articles/PMC10292733/ /pubmed/37378083 http://dx.doi.org/10.1097/CCE.0000000000000940 Text en Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Commentary
Aldhaeefi, Mohammed
Alshaya, Abdulrahman
Belrhiti, Sanaa
Rungkitwattanakul, Dhakrit
Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title_full Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title_fullStr Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title_full_unstemmed Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title_short Alternatives to Hydrocortisone for Hemodynamic Support in Septic Shock Management Due to Medication Shortage
title_sort alternatives to hydrocortisone for hemodynamic support in septic shock management due to medication shortage
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292733/
https://www.ncbi.nlm.nih.gov/pubmed/37378083
http://dx.doi.org/10.1097/CCE.0000000000000940
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