A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing

BACKGROUND: Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to id...

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Detalles Bibliográficos
Autores principales: Granell, Raquel, Curtin, John A, Haider, Sadia, Kitaba, Negusse Tadesse, Mathie, Sara A, Gregory, Lisa G, Yates, Laura L, Tutino, Mauro, Hankinson, Jenny, Perretti, Mauro, Vonk, Judith M, Arshad, Hasan S, Cullinan, Paul, Fontanella, Sara, Roberts, Graham C, Koppelman, Gerard H, Simpson, Angela, Turner, Steve W, Murray, Clare S, Lloyd, Clare M, Holloway, John W, Custovic, Adnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292845/
https://www.ncbi.nlm.nih.gov/pubmed/37227431
http://dx.doi.org/10.7554/eLife.84315

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