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Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer
INTRODUCTION: Breast conservation surgery (BCS) is the accepted standard of treatment for early breast cancer, with evidence from randomized controlled and population-based studies. The oncological outcome of BCS in locally advanced breast cancer (LABC) is mainly available from retrospective series...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cancer Intelligence
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292858/ https://www.ncbi.nlm.nih.gov/pubmed/37377681 http://dx.doi.org/10.3332/ecancer.2023.1554 |
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author | Agrawal, Sanjit Kumar Patel, Dimple Shenoy, Pradyumn Ahmed, Rosina Arun, Indu Chatterjee, Sanjoy |
author_facet | Agrawal, Sanjit Kumar Patel, Dimple Shenoy, Pradyumn Ahmed, Rosina Arun, Indu Chatterjee, Sanjoy |
author_sort | Agrawal, Sanjit Kumar |
collection | PubMed |
description | INTRODUCTION: Breast conservation surgery (BCS) is the accepted standard of treatment for early breast cancer, with evidence from randomized controlled and population-based studies. The oncological outcome of BCS in locally advanced breast cancer (LABC) is mainly available from retrospective series with a small sample size and a shorter follow-up duration. METHODS: A retrospective observational study of 411 non-metastatic LABC patients who received neoadjuvant chemotherapy (NACT) followed by surgery from 2011 to 2016. We retrieved the data from a prospectively maintained database and electronic medical records. Survival data were analyzed by Kaplan–Meier curves and Cox regression using Statistical Package for the Social Sciences 25 and STATA 14. RESULTS: 146/411 (35.5%) women had BCS with a margin positivity rate of 3.42%. With a median follow-up of 64 months (IQR 61, 66), the local relapse rate was 8.9% in BCS and 8.3% after mastectomy. The estimated 5-year locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS), distant disease-free survival (DDFS) and overall survival (OS) rates of BCS were 86.9%, 63.9%, 71% and 79.3%, and 90.1%, 57.9%, 58.3% and 71.5% in the mastectomy group. On univariate analysis, BCS showed superior survival outcomes compared to mastectomy (unadjusted HR (95% CI) for RFS: 0.70 (0.50–1), DDFS: 0.57 (0.39–0.84), OS: 0.58 (0.36–0.93)). After adjusting for age, cT stage, cN stage, poorer chemotherapy response (ypT0/is, N0) and radiotherapy, BCS and mastectomy groups were found comparable in terms of LRFS (HR: 1.1, 0.53–2.3), DDFS (HR: 0.67, 0.45–1.01), RFS (HR: 0.80, 0.55–1.17) and OS (HR: 0.69, 0.41–1.14). CONCLUSION: BCS is technically feasible in LABC patients. LABC patients who respond well to NACT can be offered BCS without compromising survival outcomes. |
format | Online Article Text |
id | pubmed-10292858 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cancer Intelligence |
record_format | MEDLINE/PubMed |
spelling | pubmed-102928582023-06-27 Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer Agrawal, Sanjit Kumar Patel, Dimple Shenoy, Pradyumn Ahmed, Rosina Arun, Indu Chatterjee, Sanjoy Ecancermedicalscience Research INTRODUCTION: Breast conservation surgery (BCS) is the accepted standard of treatment for early breast cancer, with evidence from randomized controlled and population-based studies. The oncological outcome of BCS in locally advanced breast cancer (LABC) is mainly available from retrospective series with a small sample size and a shorter follow-up duration. METHODS: A retrospective observational study of 411 non-metastatic LABC patients who received neoadjuvant chemotherapy (NACT) followed by surgery from 2011 to 2016. We retrieved the data from a prospectively maintained database and electronic medical records. Survival data were analyzed by Kaplan–Meier curves and Cox regression using Statistical Package for the Social Sciences 25 and STATA 14. RESULTS: 146/411 (35.5%) women had BCS with a margin positivity rate of 3.42%. With a median follow-up of 64 months (IQR 61, 66), the local relapse rate was 8.9% in BCS and 8.3% after mastectomy. The estimated 5-year locoregional recurrence-free survival (LRFS), recurrence-free survival (RFS), distant disease-free survival (DDFS) and overall survival (OS) rates of BCS were 86.9%, 63.9%, 71% and 79.3%, and 90.1%, 57.9%, 58.3% and 71.5% in the mastectomy group. On univariate analysis, BCS showed superior survival outcomes compared to mastectomy (unadjusted HR (95% CI) for RFS: 0.70 (0.50–1), DDFS: 0.57 (0.39–0.84), OS: 0.58 (0.36–0.93)). After adjusting for age, cT stage, cN stage, poorer chemotherapy response (ypT0/is, N0) and radiotherapy, BCS and mastectomy groups were found comparable in terms of LRFS (HR: 1.1, 0.53–2.3), DDFS (HR: 0.67, 0.45–1.01), RFS (HR: 0.80, 0.55–1.17) and OS (HR: 0.69, 0.41–1.14). CONCLUSION: BCS is technically feasible in LABC patients. LABC patients who respond well to NACT can be offered BCS without compromising survival outcomes. Cancer Intelligence 2023-05-25 /pmc/articles/PMC10292858/ /pubmed/37377681 http://dx.doi.org/10.3332/ecancer.2023.1554 Text en © the authors; licensee ecancermedicalscience. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Agrawal, Sanjit Kumar Patel, Dimple Shenoy, Pradyumn Ahmed, Rosina Arun, Indu Chatterjee, Sanjoy Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title | Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title_full | Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title_fullStr | Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title_full_unstemmed | Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title_short | Oncologic safety of breast conservation following NACT in women with locally advanced breast cancer |
title_sort | oncologic safety of breast conservation following nact in women with locally advanced breast cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292858/ https://www.ncbi.nlm.nih.gov/pubmed/37377681 http://dx.doi.org/10.3332/ecancer.2023.1554 |
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