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A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio

Introduction: We aimed to examine the D-dimer/platelet ratio (DPR), which includes the combination of D-dimer and platelet measurements, which are two important markers in predicting prognosis, considering that it will show clinical progression. Methods: After ranking the patients from high to low a...

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Autores principales: Tahmaz, Alper, Seremet Keskin, Aysegul, Kizilates, Filiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292921/
https://www.ncbi.nlm.nih.gov/pubmed/37378128
http://dx.doi.org/10.7759/cureus.39580
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author Tahmaz, Alper
Seremet Keskin, Aysegul
Kizilates, Filiz
author_facet Tahmaz, Alper
Seremet Keskin, Aysegul
Kizilates, Filiz
author_sort Tahmaz, Alper
collection PubMed
description Introduction: We aimed to examine the D-dimer/platelet ratio (DPR), which includes the combination of D-dimer and platelet measurements, which are two important markers in predicting prognosis, considering that it will show clinical progression. Methods: After ranking the patients from high to low according to DPR level, they were divided into three equal groups. Demographic, clinical, and laboratory parameters between groups were compared according to DPR level. The consistency of DPR with other coronavirus disease 2019 (COVID-19) biomarkers in the literature in terms of hospitalization and mortality in the intensive care unit was examined. Results: Complications such as renal failure, pulmonary thromboembolism (PTE), and stroke of the patients increased as the DPR increased. Patients in the third group with high DPR had higher oxygen demands from symptom onset, such as reservoir masks, high-flow oxygen, and mechanical ventilation. The first hospitalization location in the third group was determined as the intensive care unit. Mortality increased as the DPR value increased, and the time to death in patients in the third group was significantly shorter than the patients in the other two groups. While most of the patients in the first two groups recovered, 42% of the patients in the third group died. While the area under the curve was 80.6% in predicting DPR admission to the intensive care unit, the cut-off value was determined as 1.606. When the effect of DPR on predicting mortality was examined, the area under the curve for DPR was 82.6% and the cut-off value was determined as 2.284. Conclusion: DPR is successful in predicting the severity, ICU admission, and mortality of COVID-19 patients.
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spelling pubmed-102929212023-06-27 A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio Tahmaz, Alper Seremet Keskin, Aysegul Kizilates, Filiz Cureus Emergency Medicine Introduction: We aimed to examine the D-dimer/platelet ratio (DPR), which includes the combination of D-dimer and platelet measurements, which are two important markers in predicting prognosis, considering that it will show clinical progression. Methods: After ranking the patients from high to low according to DPR level, they were divided into three equal groups. Demographic, clinical, and laboratory parameters between groups were compared according to DPR level. The consistency of DPR with other coronavirus disease 2019 (COVID-19) biomarkers in the literature in terms of hospitalization and mortality in the intensive care unit was examined. Results: Complications such as renal failure, pulmonary thromboembolism (PTE), and stroke of the patients increased as the DPR increased. Patients in the third group with high DPR had higher oxygen demands from symptom onset, such as reservoir masks, high-flow oxygen, and mechanical ventilation. The first hospitalization location in the third group was determined as the intensive care unit. Mortality increased as the DPR value increased, and the time to death in patients in the third group was significantly shorter than the patients in the other two groups. While most of the patients in the first two groups recovered, 42% of the patients in the third group died. While the area under the curve was 80.6% in predicting DPR admission to the intensive care unit, the cut-off value was determined as 1.606. When the effect of DPR on predicting mortality was examined, the area under the curve for DPR was 82.6% and the cut-off value was determined as 2.284. Conclusion: DPR is successful in predicting the severity, ICU admission, and mortality of COVID-19 patients. Cureus 2023-05-27 /pmc/articles/PMC10292921/ /pubmed/37378128 http://dx.doi.org/10.7759/cureus.39580 Text en Copyright © 2023, Tahmaz et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Tahmaz, Alper
Seremet Keskin, Aysegul
Kizilates, Filiz
A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title_full A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title_fullStr A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title_full_unstemmed A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title_short A Prognostic Marker in COVID-19 Disease Severity and Mortality: D-Dimer/Platelet Ratio
title_sort prognostic marker in covid-19 disease severity and mortality: d-dimer/platelet ratio
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10292921/
https://www.ncbi.nlm.nih.gov/pubmed/37378128
http://dx.doi.org/10.7759/cureus.39580
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