An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

The Hippo pathway is a key growth control pathway that is conserved across species. The downstream effectors of the Hippo pathway, YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif), are frequently activated in cancers to drive proliferation and survival. Based...

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Detalles Bibliográficos
Autores principales: Hagenbeek, Thijs J., Zbieg, Jason R., Hafner, Marc, Mroue, Rana, Lacap, Jennifer A., Sodir, Nicole M., Noland, Cameron L., Afghani, Shervin, Kishore, Ayush, Bhat, Kamakoti P., Yao, Xiaosai, Schmidt, Stephen, Clausen, Saundra, Steffek, Micah, Lee, Wendy, Beroza, Paul, Martin, Scott, Lin, Eva, Fong, Rina, Di Lello, Paola, Kubala, Marta H., Yang, Michelle N.-Y., Lau, Jeffrey T., Chan, Emily, Arrazate, Alfonso, An, Le, Levy, Elizabeth, Lorenzo, Maria N., Lee, Ho-June, Pham, Trang H., Modrusan, Zora, Zang, Richard, Chen, Yi-Chen, Kabza, Michal, Ahmed, Musaddeque, Li, Jason, Chang, Matthew T., Maddalo, Danilo, Evangelista, Marie, Ye, Xin, Crawford, James J., Dey, Anwesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293011/
https://www.ncbi.nlm.nih.gov/pubmed/37277530
http://dx.doi.org/10.1038/s43018-023-00577-0

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