Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

BACKGROUND AND OBJECTIVE: Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. CASE: Here, we present the case of a 62-year-old patient who developed agranulocytosis...

Descripción completa

Detalles Bibliográficos
Autores principales: Allgaier, Raphael, Kandulski, Arne, Gülow, Karsten, Maier, Lars, Müller, Martina, Tews, Hauke Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293139/
https://www.ncbi.nlm.nih.gov/pubmed/36988798
http://dx.doi.org/10.1007/s40268-023-00415-9
_version_ 1785062931760676864
author Allgaier, Raphael
Kandulski, Arne
Gülow, Karsten
Maier, Lars
Müller, Martina
Tews, Hauke Christian
author_facet Allgaier, Raphael
Kandulski, Arne
Gülow, Karsten
Maier, Lars
Müller, Martina
Tews, Hauke Christian
author_sort Allgaier, Raphael
collection PubMed
description BACKGROUND AND OBJECTIVE: Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. CASE: Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. CONCLUSION: This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.
format Online
Article
Text
id pubmed-10293139
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-102931392023-06-28 Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose Allgaier, Raphael Kandulski, Arne Gülow, Karsten Maier, Lars Müller, Martina Tews, Hauke Christian Drugs R D Case Report BACKGROUND AND OBJECTIVE: Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole. CASE: Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole. CONCLUSION: This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types. Springer International Publishing 2023-03-29 2023-06 /pmc/articles/PMC10293139/ /pubmed/36988798 http://dx.doi.org/10.1007/s40268-023-00415-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Allgaier, Raphael
Kandulski, Arne
Gülow, Karsten
Maier, Lars
Müller, Martina
Tews, Hauke Christian
Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title_full Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title_fullStr Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title_full_unstemmed Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title_short Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
title_sort case report: simultaneously induced neutropenia and hemolysis after a single metamizole dose
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293139/
https://www.ncbi.nlm.nih.gov/pubmed/36988798
http://dx.doi.org/10.1007/s40268-023-00415-9
work_keys_str_mv AT allgaierraphael casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose
AT kandulskiarne casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose
AT gulowkarsten casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose
AT maierlars casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose
AT mullermartina casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose
AT tewshaukechristian casereportsimultaneouslyinducedneutropeniaandhemolysisafterasinglemetamizoledose

Ejemplares similares