Cargando…

Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy

Proximal spinal muscular atrophy (SMA) is a leading genetic cause for infant death in the world and results from the selective loss of motor neurons in the spinal cord. SMA is a consequence of low levels of SMN protein and small molecules that can increase SMN expression are of considerable interest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lumpkin, Casey J., Harris, Ashlee W., Connell, Andrew J., Kirk, Ryan W., Whiting, Joshua A., Saieva, Luciano, Pellizzoni, Livio, Burghes, Arthur H. M., Butchbach, Matthew E. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293174/ https://www.ncbi.nlm.nih.gov/pubmed/37365234 http://dx.doi.org/10.1038/s41598-023-37496-0

Ejemplares similares

Ribonucleoprotein Assembly Defects Correlate with Spinal Muscular Atrophy Severity and Preferentially Affect a Subset of Spliceosomal snRNPs
por: Gabanella, Francesca, et al.
Publicado: (2007)

Transcriptome Profiling of Spinal Muscular Atrophy Motor Neurons Derived from Mouse Embryonic Stem Cells
por: Maeda, Miho, et al.
Publicado: (2014)

On atmospheric $^{39}Ar$ and $^{42}Ar$ abundance
por: Cennini, P, et al.
Publicado: (1995)

Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice
por: Chua, Ming Jang, et al.
Publicado: (2021)

The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy
por: Liu, Hong, et al.
Publicado: (2014)

A Cell System for Phenotypic Screening of Modifiers of SMN2 Gene Expression and Function
por: Li, Darrick K., et al.
Publicado: (2013)

Copy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative Diseases
por: Butchbach, Matthew E. R.
Publicado: (2016)

Proton scattering by the unstable neutron-rich isotopes $^{42,44}Ar$
por: Scheit, H, et al.
Publicado: (2000)

Clinical and Experimental Applications of Sodium Phenylbutyrate
por: Iannitti, Tommaso, et al.
Publicado: (2012)

Identification of enzymes involved in oxidation of phenylbutyrate
por: Palir, Neža, et al.
Publicado: (2017)

Synthesis and biochemical evaluation of cephalosporin analogues equipped with chemical tethers
por: Miller, Lisa M., et al.
Publicado: (2020)

Genomic Variability in the Survival Motor Neuron Genes (SMN1 and SMN2): Implications for Spinal Muscular Atrophy Phenotype and Therapeutics Development
por: Butchbach, Matthew E. R.
Publicado: (2021)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

The effects of C5-substituted 2,4-diaminoquinazolines on selected transcript expression in spinal muscular atrophy cells
por: Gentillon, Cinsley, et al.
Publicado: (2017)

Two-proton decay of the isobaric analogue state of $^{31}$Ar
por: Mukha, I, et al.
Publicado: (1998)

Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis
por: Murahari, Sridhar, et al.
Publicado: (2017)

Pitfalls in AR42J-model of cerulein-induced acute pancreatitis
por: Hollenbach, Marcus, et al.
Publicado: (2021)

Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases
por: Rossi, Guendalina, et al.
Publicado: (2020)

Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems
por: Charroux, Bernard, et al.
Publicado: (1999)

Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
por: Van Alstyne, Meaghan, et al.
Publicado: (2018)

4-PHENYLBUTYRATE: MOLECULAR MECHANISMS AND AGING INTERVENTION POTENTIAL
por: Bene, Michael R, et al.
Publicado: (2019)

Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages
por: Rahtes, Allison, et al.
Publicado: (2019)

Shape of neutron-rich $^{42}$Ar studied by low-energy Coulomb excitation
por: Zielinska, Magda, et al.
Publicado: (2012)

Synthesis, In Vitro, and In Vivo Investigations of Pterostilbene-Tethered Analogues as Anti-Breast Cancer Candidates
por: Li, Guoxun, et al.
Publicado: (2023)

Systems Biology Investigation of cAMP Modulation to Increase SMN Levels for the Treatment of Spinal Muscular Atrophy
por: Mack, Sean G., et al.
Publicado: (2014)

Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins
por: Goncalves Monteiro, Daniela, et al.
Publicado: (2021)

SMN1 and SMN2 copy numbers in cell lines derived from patients with spinal muscular atrophy as measured by array digital PCR
por: Stabley, Deborah L, et al.
Publicado: (2015)

Effect of sodium 4-phenylbutyrate on Clenbuterol-mediated muscle growth
por: Brown, David M., et al.
Publicado: (2018)

4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells
por: Suzuki, Maiko, et al.
Publicado: (2017)

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
por: Karissa, Patricia, et al.
Publicado: (2022)

Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity
por: Lim, Wooi F., et al.
Publicado: (2021)

HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide
por: Canella, Alessandro, et al.
Publicado: (2015)

Comprehensive In Silico Analysis of Retrotransposon Insertions within the Survival Motor Neuron Genes Involved in Spinal Muscular Atrophy
por: Pinto, Albano, et al.
Publicado: (2022)

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes
por: Karagiannis, Tom C, et al.
Publicado: (2010)

Trichostatin A Promotes the Generation and Suppressive Functions of Regulatory T Cells
por: Doñas, Cristian, et al.
Publicado: (2013)

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma
por: Bai, Yunjuan, et al.
Publicado: (2018)

Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
por: Simon, Christian M., et al.
Publicado: (2019)

Adeno-associated virus serotype 9 antibody seroprevalence for patients in the United States with spinal muscular atrophy
por: Day, John W., et al.
Publicado: (2023)

Correction: HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide
por: Canella, Alessandro, et al.
Publicado: (2023)

Modulation of Toxin Stability by 4-Phenylbutyric Acid and Negatively Charged Phospholipids
por: Ray, Supriyo, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_61tmk5uhd23p4p22otoc393qj6