CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease

In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4(+) T cell recruitment and mediate an α-syn-induced inflammatory makeup.

Detalles Bibliográficos
Autores principales: Frosch, Maximilian, Amann, Lukas, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293184/
https://www.ncbi.nlm.nih.gov/pubmed/37365158
http://dx.doi.org/10.1038/s41467-023-39061-9
Descripción
Sumario:In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4(+) T cell recruitment and mediate an α-syn-induced inflammatory makeup.

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