CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease

In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4(+) T cell recruitment and mediate an α-syn-induced inflammatory makeup.

Detalles Bibliográficos
Autores principales: Frosch, Maximilian, Amann, Lukas, Prinz, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293184/
https://www.ncbi.nlm.nih.gov/pubmed/37365158
http://dx.doi.org/10.1038/s41467-023-39061-9
_version_ 1785062940232122368
author Frosch, Maximilian
Amann, Lukas
Prinz, Marco
author_facet Frosch, Maximilian
Amann, Lukas
Prinz, Marco
author_sort Frosch, Maximilian
collection PubMed
description In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4(+) T cell recruitment and mediate an α-syn-induced inflammatory makeup.
format Online
Article
Text
id pubmed-10293184
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102931842023-06-28 CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease Frosch, Maximilian Amann, Lukas Prinz, Marco Nat Commun Comment In an alpha-synuclein (α-syn) model of Parkinson’s disease (PD), Schonhoff and colleagues have shown that central nervous system (CNS)-associated macrophages (CAMs), but not microglia, potentially orchestrate CD4(+) T cell recruitment and mediate an α-syn-induced inflammatory makeup. Nature Publishing Group UK 2023-06-26 /pmc/articles/PMC10293184/ /pubmed/37365158 http://dx.doi.org/10.1038/s41467-023-39061-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Frosch, Maximilian
Amann, Lukas
Prinz, Marco
CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title_full CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title_fullStr CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title_full_unstemmed CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title_short CNS-associated macrophages shape the inflammatory response in a mouse model of Parkinson’s disease
title_sort cns-associated macrophages shape the inflammatory response in a mouse model of parkinson’s disease
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293184/
https://www.ncbi.nlm.nih.gov/pubmed/37365158
http://dx.doi.org/10.1038/s41467-023-39061-9
work_keys_str_mv AT froschmaximilian cnsassociatedmacrophagesshapetheinflammatoryresponseinamousemodelofparkinsonsdisease
AT amannlukas cnsassociatedmacrophagesshapetheinflammatoryresponseinamousemodelofparkinsonsdisease
AT prinzmarco cnsassociatedmacrophagesshapetheinflammatoryresponseinamousemodelofparkinsonsdisease

Ejemplares similares