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The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and ident...

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Autores principales: Zhou, Meng, Bao, Siqi, Gong, Tongyang, Wang, Qiang, Sun, Jie, Li, Jiaqi, Lu, Minyi, Sun, Wanyuan, Su, Jianzhong, Chen, Hongyan, Liu, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293239/
https://www.ncbi.nlm.nih.gov/pubmed/37365153
http://dx.doi.org/10.1038/s41467-023-39530-1
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author Zhou, Meng
Bao, Siqi
Gong, Tongyang
Wang, Qiang
Sun, Jie
Li, Jiaqi
Lu, Minyi
Sun, Wanyuan
Su, Jianzhong
Chen, Hongyan
Liu, Zhihua
author_facet Zhou, Meng
Bao, Siqi
Gong, Tongyang
Wang, Qiang
Sun, Jie
Li, Jiaqi
Lu, Minyi
Sun, Wanyuan
Su, Jianzhong
Chen, Hongyan
Liu, Zhihua
author_sort Zhou, Meng
collection PubMed
description Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC.
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spelling pubmed-102932392023-06-28 The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma Zhou, Meng Bao, Siqi Gong, Tongyang Wang, Qiang Sun, Jie Li, Jiaqi Lu, Minyi Sun, Wanyuan Su, Jianzhong Chen, Hongyan Liu, Zhihua Nat Commun Article Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC. Nature Publishing Group UK 2023-06-26 /pmc/articles/PMC10293239/ /pubmed/37365153 http://dx.doi.org/10.1038/s41467-023-39530-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhou, Meng
Bao, Siqi
Gong, Tongyang
Wang, Qiang
Sun, Jie
Li, Jiaqi
Lu, Minyi
Sun, Wanyuan
Su, Jianzhong
Chen, Hongyan
Liu, Zhihua
The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title_full The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title_fullStr The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title_full_unstemmed The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title_short The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma
title_sort transcriptional landscape and diagnostic potential of long non-coding rnas in esophageal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293239/
https://www.ncbi.nlm.nih.gov/pubmed/37365153
http://dx.doi.org/10.1038/s41467-023-39530-1
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