Cargando…

Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score

Major post-cessation metabolic changes include weight gain and hyperglycemia. However, the association of post-cessation change in fasting serum glucose (FSG) with risk of fatty liver remains unclear. A total of 111,106 participants aged 40 and above who underwent health screening at least once in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Saemi, Jeong, Seogsong, Ahn, Joseph C., Cho, Yoosun, Choi, Seulggie, Park, Sun Jae, Kim, Kyae Hyung, Lee, Gyeongsil, Son, Joung Sik, Park, Sang Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293240/
https://www.ncbi.nlm.nih.gov/pubmed/37365204
http://dx.doi.org/10.1038/s41598-023-37194-x
_version_ 1785062957895385088
author Han, Saemi
Jeong, Seogsong
Ahn, Joseph C.
Cho, Yoosun
Choi, Seulggie
Park, Sun Jae
Kim, Kyae Hyung
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
author_facet Han, Saemi
Jeong, Seogsong
Ahn, Joseph C.
Cho, Yoosun
Choi, Seulggie
Park, Sun Jae
Kim, Kyae Hyung
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
author_sort Han, Saemi
collection PubMed
description Major post-cessation metabolic changes include weight gain and hyperglycemia. However, the association of post-cessation change in fasting serum glucose (FSG) with risk of fatty liver remains unclear. A total of 111,106 participants aged 40 and above who underwent health screening at least once in two examination periods were extracted from the Korean National Health Insurance Service-National Sample Cohort. Fatty liver status was evaluated using the Korean National Health and Nutrition Examination Survey nonalcoholic fatty liver disease (K-NAFLD) score. Linear and logistic regression were used to calculate the adjusted mean (aMean) and adjusted odds ratio (aOR) with 95% confidence intervals. Compared to stable (aMean 0.10; 95% CI 0.03–0.18) and decline (aMean − 0.60; 95% CI − 0.71 to 0.49) groups, FSG elevation (aMean 1.28; 95% CI 1.16–1.39) was associated with higher K-NAFLD score even within different body mass index change groups. Risk of fatty liver was significantly reduced among participants with stable (aOR 0.38; 95% CI 0.31–0.45) and declined (aOR 0.17; 95% CI 0.13–0.22) FSG levels after smoking cessation compared to FSG elevation group. This study suggests that quitters with elevated FSG are associated with higher NAFLD risk and may benefit from careful monitoring of FSG levels and management of other cardiovascular risk factors.
format Online
Article
Text
id pubmed-10293240
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-102932402023-06-28 Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score Han, Saemi Jeong, Seogsong Ahn, Joseph C. Cho, Yoosun Choi, Seulggie Park, Sun Jae Kim, Kyae Hyung Lee, Gyeongsil Son, Joung Sik Park, Sang Min Sci Rep Article Major post-cessation metabolic changes include weight gain and hyperglycemia. However, the association of post-cessation change in fasting serum glucose (FSG) with risk of fatty liver remains unclear. A total of 111,106 participants aged 40 and above who underwent health screening at least once in two examination periods were extracted from the Korean National Health Insurance Service-National Sample Cohort. Fatty liver status was evaluated using the Korean National Health and Nutrition Examination Survey nonalcoholic fatty liver disease (K-NAFLD) score. Linear and logistic regression were used to calculate the adjusted mean (aMean) and adjusted odds ratio (aOR) with 95% confidence intervals. Compared to stable (aMean 0.10; 95% CI 0.03–0.18) and decline (aMean − 0.60; 95% CI − 0.71 to 0.49) groups, FSG elevation (aMean 1.28; 95% CI 1.16–1.39) was associated with higher K-NAFLD score even within different body mass index change groups. Risk of fatty liver was significantly reduced among participants with stable (aOR 0.38; 95% CI 0.31–0.45) and declined (aOR 0.17; 95% CI 0.13–0.22) FSG levels after smoking cessation compared to FSG elevation group. This study suggests that quitters with elevated FSG are associated with higher NAFLD risk and may benefit from careful monitoring of FSG levels and management of other cardiovascular risk factors. Nature Publishing Group UK 2023-06-26 /pmc/articles/PMC10293240/ /pubmed/37365204 http://dx.doi.org/10.1038/s41598-023-37194-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Han, Saemi
Jeong, Seogsong
Ahn, Joseph C.
Cho, Yoosun
Choi, Seulggie
Park, Sun Jae
Kim, Kyae Hyung
Lee, Gyeongsil
Son, Joung Sik
Park, Sang Min
Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title_full Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title_fullStr Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title_full_unstemmed Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title_short Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
title_sort association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293240/
https://www.ncbi.nlm.nih.gov/pubmed/37365204
http://dx.doi.org/10.1038/s41598-023-37194-x
work_keys_str_mv AT hansaemi associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT jeongseogsong associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT ahnjosephc associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT choyoosun associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT choiseulggie associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT parksunjae associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT kimkyaehyung associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT leegyeongsil associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT sonjoungsik associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore
AT parksangmin associationofpostsmokingcessationchangesinfastingserumglucosewithchangesinpredictedfattyliverscore