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Coexisting ecotypes in long-term evolution emerged from interacting trade-offs

Evolution of complex communities of coexisting microbes remains poorly understood. The long-term evolution experiment on Escherichia coli (LTEE) revealed the spontaneous emergence of stable coexistence of multiple ecotypes, which persisted for more than 14,000 generations of continuous evolution. He...

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Autores principales: Mukherjee, Avik, Ealy, Jade, Huang, Yanqing, Benites, Nina Catherine, Polk, Mark, Basan, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293278/
https://www.ncbi.nlm.nih.gov/pubmed/37365188
http://dx.doi.org/10.1038/s41467-023-39471-9
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author Mukherjee, Avik
Ealy, Jade
Huang, Yanqing
Benites, Nina Catherine
Polk, Mark
Basan, Markus
author_facet Mukherjee, Avik
Ealy, Jade
Huang, Yanqing
Benites, Nina Catherine
Polk, Mark
Basan, Markus
author_sort Mukherjee, Avik
collection PubMed
description Evolution of complex communities of coexisting microbes remains poorly understood. The long-term evolution experiment on Escherichia coli (LTEE) revealed the spontaneous emergence of stable coexistence of multiple ecotypes, which persisted for more than 14,000 generations of continuous evolution. Here, using a combination of experiments and computer simulations, we show that the emergence and persistence of this phenomenon can be explained by the combination of two interacting trade-offs, rooted in biochemical constraints: First, faster growth is enabled by higher fermentation and obligate acetate excretion. Second, faster growth results in longer lag times when utilizing acetate after glucose is depleted. This combination creates an ecological niche for a slower-growing ecotype, specialized in switching to acetate. These findings demonstrate that trade-offs can give rise to surprisingly complex communities with evolutionarily stable coexistence of multiple variants in even the simplest environments.
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spelling pubmed-102932782023-06-28 Coexisting ecotypes in long-term evolution emerged from interacting trade-offs Mukherjee, Avik Ealy, Jade Huang, Yanqing Benites, Nina Catherine Polk, Mark Basan, Markus Nat Commun Article Evolution of complex communities of coexisting microbes remains poorly understood. The long-term evolution experiment on Escherichia coli (LTEE) revealed the spontaneous emergence of stable coexistence of multiple ecotypes, which persisted for more than 14,000 generations of continuous evolution. Here, using a combination of experiments and computer simulations, we show that the emergence and persistence of this phenomenon can be explained by the combination of two interacting trade-offs, rooted in biochemical constraints: First, faster growth is enabled by higher fermentation and obligate acetate excretion. Second, faster growth results in longer lag times when utilizing acetate after glucose is depleted. This combination creates an ecological niche for a slower-growing ecotype, specialized in switching to acetate. These findings demonstrate that trade-offs can give rise to surprisingly complex communities with evolutionarily stable coexistence of multiple variants in even the simplest environments. Nature Publishing Group UK 2023-06-26 /pmc/articles/PMC10293278/ /pubmed/37365188 http://dx.doi.org/10.1038/s41467-023-39471-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mukherjee, Avik
Ealy, Jade
Huang, Yanqing
Benites, Nina Catherine
Polk, Mark
Basan, Markus
Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title_full Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title_fullStr Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title_full_unstemmed Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title_short Coexisting ecotypes in long-term evolution emerged from interacting trade-offs
title_sort coexisting ecotypes in long-term evolution emerged from interacting trade-offs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293278/
https://www.ncbi.nlm.nih.gov/pubmed/37365188
http://dx.doi.org/10.1038/s41467-023-39471-9
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