Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway

Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the brain. The contribution of these targets to fragile X syndrome (FXS) and related autism spectrum disorder (ASD) remains unclear. Here, we show that FMRP deficiency leads to elevated microtubule-associated protein 1...

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Detalles Bibliográficos
Autores principales: Guo, Yu, Shen, Minjie, Dong, Qiping, Méndez-Albelo, Natasha M., Huang, Sabrina X., Sirois, Carissa L., Le, Jonathan, Li, Meng, Jarzembowski, Ezra D., Schoeller, Keegan A., Stockton, Michael E., Horner, Vanessa L., Sousa, André M. M., Gao, Yu, Levine, Jon E., Wang, Daifeng, Chang, Qiang, Zhao, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293283/
https://www.ncbi.nlm.nih.gov/pubmed/37365192
http://dx.doi.org/10.1038/s41467-023-39337-0

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