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Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years

In this study of early functional changes in Parkinson’s disease (PD), we aimed to provide a comprehensive assessment of the development of changes in both cortical and subcortical neurophysiological brain activity, including their association with clinical measures of disease severity. Repeated res...

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Autores principales: Boon, Lennard I., Hillebrand, Arjan, Schoonheim, Menno M., Twisk, Jos W., Stam, Cornelis J., Berendse, Henk W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293384/
https://www.ncbi.nlm.nih.gov/pubmed/37154884
http://dx.doi.org/10.1007/s10548-023-00965-w
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author Boon, Lennard I.
Hillebrand, Arjan
Schoonheim, Menno M.
Twisk, Jos W.
Stam, Cornelis J.
Berendse, Henk W.
author_facet Boon, Lennard I.
Hillebrand, Arjan
Schoonheim, Menno M.
Twisk, Jos W.
Stam, Cornelis J.
Berendse, Henk W.
author_sort Boon, Lennard I.
collection PubMed
description In this study of early functional changes in Parkinson’s disease (PD), we aimed to provide a comprehensive assessment of the development of changes in both cortical and subcortical neurophysiological brain activity, including their association with clinical measures of disease severity. Repeated resting-state MEG recordings and clinical assessments were obtained in the context of a unique longitudinal cohort study over a seven-year period using a multiple longitudinal design. We used linear mixed-models to analyze the relationship between neurophysiological (spectral power and functional connectivity) and clinical data. At baseline, early-stage (drug-naïve) PD patients demonstrated spectral slowing compared to healthy controls in both subcortical and cortical brain regions, most outspoken in the latter. Over time, spectral slowing progressed in strong association with clinical measures of disease progression (cognitive and motor). Global functional connectivity was not different between groups at baseline and hardly changed over time. Therefore, investigation of associations with clinical measures of disease progression were not deemed useful. An analysis of individual connections demonstrated differences between groups at baseline (higher frontal theta, lower parieto-occipital alpha2 band functional connectivity) and over time in PD patients (increase in frontal delta and theta band functional connectivity). Our results suggest that spectral measures are promising candidates in the search for non-invasive markers of both early-stage PD and of the ongoing disease process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10548-023-00965-w.
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spelling pubmed-102933842023-06-28 Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years Boon, Lennard I. Hillebrand, Arjan Schoonheim, Menno M. Twisk, Jos W. Stam, Cornelis J. Berendse, Henk W. Brain Topogr Original Paper In this study of early functional changes in Parkinson’s disease (PD), we aimed to provide a comprehensive assessment of the development of changes in both cortical and subcortical neurophysiological brain activity, including their association with clinical measures of disease severity. Repeated resting-state MEG recordings and clinical assessments were obtained in the context of a unique longitudinal cohort study over a seven-year period using a multiple longitudinal design. We used linear mixed-models to analyze the relationship between neurophysiological (spectral power and functional connectivity) and clinical data. At baseline, early-stage (drug-naïve) PD patients demonstrated spectral slowing compared to healthy controls in both subcortical and cortical brain regions, most outspoken in the latter. Over time, spectral slowing progressed in strong association with clinical measures of disease progression (cognitive and motor). Global functional connectivity was not different between groups at baseline and hardly changed over time. Therefore, investigation of associations with clinical measures of disease progression were not deemed useful. An analysis of individual connections demonstrated differences between groups at baseline (higher frontal theta, lower parieto-occipital alpha2 band functional connectivity) and over time in PD patients (increase in frontal delta and theta band functional connectivity). Our results suggest that spectral measures are promising candidates in the search for non-invasive markers of both early-stage PD and of the ongoing disease process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10548-023-00965-w. Springer US 2023-05-08 2023 /pmc/articles/PMC10293384/ /pubmed/37154884 http://dx.doi.org/10.1007/s10548-023-00965-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Boon, Lennard I.
Hillebrand, Arjan
Schoonheim, Menno M.
Twisk, Jos W.
Stam, Cornelis J.
Berendse, Henk W.
Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title_full Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title_fullStr Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title_full_unstemmed Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title_short Cortical and Subcortical Changes in MEG Activity Reflect Parkinson’s Progression over a Period of 7 Years
title_sort cortical and subcortical changes in meg activity reflect parkinson’s progression over a period of 7 years
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293384/
https://www.ncbi.nlm.nih.gov/pubmed/37154884
http://dx.doi.org/10.1007/s10548-023-00965-w
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