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Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention
Cantharidin (CTD), a natural compound derived from Mylabris, is widely used in traditional Oriental medicine for its potent anticancer properties. However, its clinical application is restricted due to its high toxicity, particularly towards the liver. This review provides a concise understanding of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293652/ https://www.ncbi.nlm.nih.gov/pubmed/37383714 http://dx.doi.org/10.3389/fphar.2023.1201404 |
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author | Jin, Dian Huang, Na-Na Wei, Jing-Xia |
author_facet | Jin, Dian Huang, Na-Na Wei, Jing-Xia |
author_sort | Jin, Dian |
collection | PubMed |
description | Cantharidin (CTD), a natural compound derived from Mylabris, is widely used in traditional Oriental medicine for its potent anticancer properties. However, its clinical application is restricted due to its high toxicity, particularly towards the liver. This review provides a concise understanding of the hepatotoxic mechanisms of CTD and highlights novel therapeutic strategies to mitigate its toxicity while enhancing its anticancer efficacy. We systematically explore the molecular mechanisms underlying CTD-induced hepatotoxicity, focusing on the involvement of apoptotic and autophagic processes in hepatocyte injury. We further discuss the endogenous and exogenous pathways implicated in CTD-induced liver damage and potential therapeutic targets. This review also summarizes the structural modifications of CTD derivatives and their impact on anticancer activity. Additionally, we delve into the advancements in nanoparticle-based drug delivery systems that hold promise in overcoming the limitations of CTD derivatives. By offering valuable insights into the hepatotoxic mechanisms of CTD and outlining potential avenues for future research, this review contributes to the ongoing efforts to develop safer and more effective CTD-based therapies. |
format | Online Article Text |
id | pubmed-10293652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102936522023-06-28 Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention Jin, Dian Huang, Na-Na Wei, Jing-Xia Front Pharmacol Pharmacology Cantharidin (CTD), a natural compound derived from Mylabris, is widely used in traditional Oriental medicine for its potent anticancer properties. However, its clinical application is restricted due to its high toxicity, particularly towards the liver. This review provides a concise understanding of the hepatotoxic mechanisms of CTD and highlights novel therapeutic strategies to mitigate its toxicity while enhancing its anticancer efficacy. We systematically explore the molecular mechanisms underlying CTD-induced hepatotoxicity, focusing on the involvement of apoptotic and autophagic processes in hepatocyte injury. We further discuss the endogenous and exogenous pathways implicated in CTD-induced liver damage and potential therapeutic targets. This review also summarizes the structural modifications of CTD derivatives and their impact on anticancer activity. Additionally, we delve into the advancements in nanoparticle-based drug delivery systems that hold promise in overcoming the limitations of CTD derivatives. By offering valuable insights into the hepatotoxic mechanisms of CTD and outlining potential avenues for future research, this review contributes to the ongoing efforts to develop safer and more effective CTD-based therapies. Frontiers Media S.A. 2023-06-13 /pmc/articles/PMC10293652/ /pubmed/37383714 http://dx.doi.org/10.3389/fphar.2023.1201404 Text en Copyright © 2023 Jin, Huang and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Jin, Dian Huang, Na-Na Wei, Jing-Xia Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title | Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title_full | Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title_fullStr | Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title_full_unstemmed | Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title_short | Hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
title_sort | hepatotoxic mechanism of cantharidin: insights and strategies for therapeutic intervention |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293652/ https://www.ncbi.nlm.nih.gov/pubmed/37383714 http://dx.doi.org/10.3389/fphar.2023.1201404 |
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