Targeting DPP4-RBD interactions by sitagliptin and linagliptin delivers a potential host-directed therapy against pan-SARS-CoV-2 infections

Highly mutated SARS-CoV-2 is known aetiological factor for COVID-19. Here, we have demonstrated that the receptor binding domain (RBD) of the spike protein can interact with human dipeptidyl peptidase 4 (DPP4) to facilitate virus entry, in addition to the usual route of ACE2-RBD binding. Significant...

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Detalles Bibliográficos
Autores principales: Mani, Shailendra, Kaur, Anupamjeet, Jakhar, Kamini, Kumari, Geetika, Sonar, Sudipta, Kumar, Amit, Das, Sudesna, Kumar, Santosh, Kumar, Vijay, Kundu, Rakesh, Pandey, Anil Kumar, Singh, Umesh Prasad, Majumdar, Tanmay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293653/
https://www.ncbi.nlm.nih.gov/pubmed/37385308
http://dx.doi.org/10.1016/j.ijbiomac.2023.125444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293653/
https://www.ncbi.nlm.nih.gov/pubmed/37385308
http://dx.doi.org/10.1016/j.ijbiomac.2023.125444

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