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Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy

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Cobalamin-dependent methionine synthase (MetH) catalyzes the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate (CH(3)-H(4)folate) using the unique chemistry of its cofactor. In doing so, MetH links the cycling of S-adenosylmethionine with the folate cycle in one-carbon metabolis...

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Detalles Bibliográficos
Autores principales:	Watkins, Maxwell B., Wang, Haoyue, Burnim, Audrey, Ando, Nozomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293825/ https://www.ncbi.nlm.nih.gov/pubmed/37339208 http://dx.doi.org/10.1073/pnas.2302531120

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