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Contribution of the IGCR1 regulatory element and the 3′Igh CTCF-binding elements to regulation of Igh V(D)J recombination

Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells, from V(H), D, and J(H) gene segments located in separate clusters across the Igh locus. RAG endonuclease initiates V(D)J recombination from a J(H)-based recombination center (RC). Cohesin-mediated extrusion of upst...

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Detalles Bibliográficos
Autores principales:	Liang, Zhuoyi, Zhao, Lijuan, Ye, Adam Yongxin, Lin, Sherry G., Zhang, Yiwen, Guo, Chunguang, Dai, Hai-Qiang, Ba, Zhaoqing, Alt, Frederick W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293834/ https://www.ncbi.nlm.nih.gov/pubmed/37339228 http://dx.doi.org/10.1073/pnas.2306564120

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